微rna与肺癌:信号通路和治疗的焦点

IF 0.2 Q4 Biochemistry, Genetics and Molecular Biology

Research Journal of Biotechnology Pub Date : 2023-09-15 DOI:10.25303/1810rjbt2410248

Sohom Banerjee, Sharanya Koilerian, Abul Kalam Azad Mandal

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引用次数: 0

摘要

微RNA是一种短序列的单链RNA，不编码蛋白质，但在调节细胞中的基因表达方面起着至关重要的作用。微rna可以下调基因的表达，并可以改变对细胞正常功能至关重要的不同途径。微rna作为潜在的生物标志物和治疗靶点有效地治疗包括肺癌在内的多种疾病。本文综述了肺癌中表达的不同微rna及其在Wnt、RAS/RAF、PI3K/Akt通路等不同信号通路中的靶点。我们还评估了目前基于微rna的治疗小细胞肺癌和非小细胞肺癌的现状，无论是在临床前研究的背景下，还是在人体上进行的临床研究中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Micro-RNAs and lung cancer: A focus on signaling pathways and therapeutics

Micro-RNAs are short sequences of single-stranded RNA that do not code for proteins but play a crucial role in modulating gene expression in the cell. Micro-RNAs can downregulate the expression of genes and can modify different pathways that are important for proper functioning of the cells. Micro-RNAs are effective as potential biomarkers and therapeutic targets against various diseases including lung cancer. In this review, we take a look at the different micro-RNAs expressed in lung cancer and their targets in various signaling pathways like Wnt, RAS/RAF, PI3K/Akt pathway etc. We also evaluate the current status of micro-RNA - based therapeutics against Small Cell Lung Cancer and Non-Small Cell Lung Cancer, both in the context of pre-clinical studies as well as clinical studies conducted on humans to date.

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来源期刊

Research Journal of Biotechnology 工程技术-生物工程与应用微生物

CiteScore

0.60

自引率

0.00%

发文量

192

审稿时长

1.5 months

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