{"title":"瘦素抵抗小鼠神经肌肉关节功能损伤","authors":"V. A. Prikhodko, T. M. Matuzok, S. V. Okovityi","doi":"10.33647/2074-5982-19-3-77-81","DOIUrl":null,"url":null,"abstract":"The study was aimed at exploring and describing the main parameters of neuromuscular joint function in young adult leptin-resistant C57Bl/Ks-db + / + m (db/db) mice. The experiment was carried out on 10 4-month-old male db/db mice and 10 male wild-type control mice, using stimulation electroneuromyography to assess M-wave parameters for m. gastrocnemius and m. biceps brachii . We discovered a decrease in maximal amplitudes along with an increase in the M-wave latency and duration, indicating the presence of combined axonal and demyelinating peripheral nerve injury.","PeriodicalId":40514,"journal":{"name":"Avances en Biomedicina","volume":"2012 1","pages":"0"},"PeriodicalIF":0.1000,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Neuromuscular Joint Function Impairment in Leptin-Resistant Mice\",\"authors\":\"V. A. Prikhodko, T. M. Matuzok, S. V. Okovityi\",\"doi\":\"10.33647/2074-5982-19-3-77-81\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The study was aimed at exploring and describing the main parameters of neuromuscular joint function in young adult leptin-resistant C57Bl/Ks-db + / + m (db/db) mice. The experiment was carried out on 10 4-month-old male db/db mice and 10 male wild-type control mice, using stimulation electroneuromyography to assess M-wave parameters for m. gastrocnemius and m. biceps brachii . We discovered a decrease in maximal amplitudes along with an increase in the M-wave latency and duration, indicating the presence of combined axonal and demyelinating peripheral nerve injury.\",\"PeriodicalId\":40514,\"journal\":{\"name\":\"Avances en Biomedicina\",\"volume\":\"2012 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.1000,\"publicationDate\":\"2023-10-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Avances en Biomedicina\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.33647/2074-5982-19-3-77-81\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Avances en Biomedicina","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33647/2074-5982-19-3-77-81","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
摘要
本研究旨在探索和描述年轻成年瘦素抵抗C57Bl/Ks-db + / + m (db/db)小鼠神经肌肉关节功能的主要参数。以10只4月龄雄性db/db小鼠和10只野生型对照小鼠为实验对象，采用刺激神经肌电图法评估腓肠肌支原体和肱二头肌支原体的m波参数。我们发现最大振幅下降，同时m波潜伏期和持续时间增加，表明存在轴突和脱髓鞘联合周围神经损伤。
Neuromuscular Joint Function Impairment in Leptin-Resistant Mice
The study was aimed at exploring and describing the main parameters of neuromuscular joint function in young adult leptin-resistant C57Bl/Ks-db + / + m (db/db) mice. The experiment was carried out on 10 4-month-old male db/db mice and 10 male wild-type control mice, using stimulation electroneuromyography to assess M-wave parameters for m. gastrocnemius and m. biceps brachii . We discovered a decrease in maximal amplitudes along with an increase in the M-wave latency and duration, indicating the presence of combined axonal and demyelinating peripheral nerve injury.
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