MIR155HG和TNF-α在评价系统性红斑狼疮患者预后中的作用

IF 2 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Medical Biochemistry Pub Date : 2023-10-22 DOI:10.5937/jomb0-45870

Xiaojing Gu, Hu Chen, Rongping Li, Dibin Guo

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引用次数: 0

摘要

背景:研究微核糖核酸(miR)-155宿主基因(MIR155HG)和肿瘤坏死因子-α (TNF-α)在评价系统性红斑狼疮(SLE)患者预后中的作用。方法:选取我院收治的SLE患者130例，给予SLE疾病活动性指数(SLEDAI)评分。采用定量逆转录聚合酶链反应(qRT-PCR)检测MIR155HG、TNF-α的表达，观察治疗过程中并发症的发生情况，分析治疗前MIR155HG、TNF-α与SLEDAI及并发症的相关性。所有患者出院后均进行随访，通过Cox回归分析影响患者预后的相关因素。结果:SLEDAI评分为10-14分的患者MIR155HG和TNF-α水平高于SLEDAI评分为5-9分和0-4分的患者。MIR155HG、TNF-α与感染发生率、肾损害发生率、心脏损害发生率呈正相关。此外，SLE患者血清MIR155HG与TNF-α的表达也存在正相关。SLEDAI评分≥10分、住院期间并发症、MIR155HG、TNF-α高表达是影响患者预后的危险因素。结论:MIR155HG和TNF-α是SLE发病的关键调控因子，影响患者预后。这一发现为SLE的治疗提供了潜在的新靶点。

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Roles of MIR155HG and TNF-α in Evaluation of Prognosis of Patients with Systemic Lupus Erythematosus

Background: To study the roles of micro ribonucleic acid (miR)-155 host gene (MIR155HG) and tumor necrosis factor-α (TNF-α) in the evaluation of prognosis of patients with systemic lupus erythematosus (SLE). Methods: A total of 130 patients with SLE admitted to our hospital were selected, and the SLE disease activity index (SLEDAI) score was given. The expressions of MIR155HG and TNF-α were detected via quantitative reverse transcription-polymerase chain reaction (qRT-PCR), the incidence of complications during treatment was observed, and the associations of MIR155HG and TNF-α with SLEDAI before treatment and complications were analyzed. All patients were followed up after discharge, and the related factors to the prognosis of patients were analyzed via Cox regression analysis. Results: The levels of MIR155HG and TNF-α were higher in patients with an SLEDAI score of 10-14 points than those in patients with an SLEDAI score of 5-9 points and 0-4 points. MIR155HG and TNF-α were positively correlated with the incidence of infection, renal damage and cardiac damage. Moreover, there was also a positive correlation between the expressions of serum MIR155HG and TNF-α in SLE patients. SLEDAI score ≥10 points, complications during hospitalization, and highly-expressed MIR155HG and TNF-α were risk factors related to the prognosis of patients. Conclusion: MIR155HG and TNF-α are key regulators in the pathogenesis of SLE, and they can affect the prognosis of patients. Such a finding provides potential new targets for the treatment of SLE.

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来源期刊

Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

12.00%

发文量

审稿时长

>12 weeks

期刊介绍： The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.