A Comparative Study between Effect of Clomiphene Citrate and Letrozole on Endometrial Vascular Indices in Patients with Polycystic Ovarian Syndrome

Background; Polycystic ovarian syndrome is one of common causes of infertility in reproductive-age females. Clomiphene citrate & letrozole are commonly used to induce ovulation, although they are antiestrogenic. Aim and objectives; to assess the role of clomiphene citrate & letrozole in helping ovulation and conception to occur and their impact on the receptivity of the endometrium of polycystic ovarian syndrome patients, Subjects and methods; In this study there were two groups of anovulatory PCOS patients each group included 50 patients who attended Al-Hussein University Hospital outpatient infertility and Gynecology clinic during the period from March 2022 till September 2022. All studied cases were subjected to: Detailed history taking, Thorough general & pelvic examination and Transvaginal Ultrasonography, Result; There was high variation between the two studied groups regarding endometrial vascular indices on day 21 of menstruation post-treatment. Conclusion; Endometrial receptivity in letrozole group is superior to clomiphene citrate group in PCOS females throughout the implantation window, that can be linked to better conception rates and ongoing pregnancy rates. Certain issues, even though, were not addressed in this research and must be addressed in future research, such as cumulative outcomes of 6 cycles, raising dose in non-responders & occurrence of miscarriage,