基于纳米乳的真菌感染治疗管理的超分子药物传递系统

Q2 Pharmacology, Toxicology and Pharmaceutics

Drug Delivery Letters Pub Date : 2023-09-15 DOI:10.2174/2210303113666230915103016

Surjeet Kaur Sethi, Honey Goel, Viney Chawla

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引用次数: 0

摘要

摘要:真菌感染是全球死亡的重要原因之一。在治疗这些感染时，抗真菌药物与几种副作用和毒性有关。为了克服这些抗真菌药物的物理化学和药代动力学副作用，可以采用超分子给药系统。基于乳化剂的超分子组件，即微乳和纳米乳，可以被功能化以实现抗真菌药物在所需身体部位的靶向递送。基于乳液的超分子组件能够最大限度地减少与抗真菌药物相关的副作用，并提高其有效性和安全性。现就严重真菌感染及其治疗的抗真菌药物及其缺点作一综述。本文还介绍了各种基于乳化剂的超分子给药方法，这些方法可以提高抗真菌药物的可用性或减少其治疗真菌感染的副作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Nanoemulsion based Supramolecular Drug Delivery Systems for Therapeutic Management of fungal Infections

Abstract: Fungal infections are one of the significant causes of death worldwide. Antifungal agents are associated with several side effects and toxicities while treating these infections. To overcome these physicochemical and pharmacokinetic side effects of antifungal agents, supramolecular drug delivery systems can be employed. The emulsion-based supramolecular assemblies, i.e., microemulsion and nanoemulsion, can be functionalized to achieve targeted delivery of antifungal drugs at the desired body sites. Emulsion based supramolecular assemblies have the ability to minimize the side effects related to antifungal agents and enhance their efficacy and safety profile. The present review focuses on the severe fungal infections and antifungal agents available for their management with their drawbacks. This review also introduces various emulsion-based supramolecular drug delivery approaches that may improve the usability of antifungal agents or reduce their side effects to treat fungal infections.

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来源期刊

Drug Delivery Letters Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

CiteScore

1.70

自引率

0.00%

发文量