杨梅素通过NF-κB途径抑制小翅虫横纹肌病毒感染

Q1 Agricultural and Biological Sciences
Zhiwen Wang, Ping Deng, Zemao Gu, Lijuan Li, Junfa Yuan
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引用次数: 0

摘要

近年来,大口黑鲈受到由细菌、寄生虫和病毒引起的疾病的困扰,特别是病毒性疾病,造成了重大的经济损失。水产养殖业也缺乏经批准的抗病毒药物。鲑鱼小翼虫横纹肌病毒(MSRV)是鲑鱼小翼虫横纹肌病毒病的病原体,主要影响大口黑鲈鱼苗。通过实验感染、转录组测序和抑制剂治疗,验证了丝裂原活化蛋白激酶(MAPK)、磷脂酰肌醇激酶(PI3K)和核因子κ b (NF-κB)途径介导的炎症反应是MSRV感染的病理过程之一。进一步选择杨梅素、青蒿素、柚皮素、熊果酸、穿心莲内酯和白藜芦醇,根据NF-κB的启动子来进化其抗炎活性,发现杨梅素、柚皮素、穿心莲内酯和白藜芦醇显著抑制NF-κ b1启动子活性。杨梅素通过抑制NF-κB信号传导抑制MSRV引起的炎症并抑制MSRV感染。此外,杨梅素还能提高感染MSRV的大口黑鲈的存活率。综上所述,杨梅素通过靶向NF-κB炎症通路具有抗msrv活性,可作为一种潜在的横纹肌病毒疾病预防药物进一步开发。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Myricetin inhibits Micropterus salmoides rhabdovirus infection by damping inflammation through the NF-κB pathway
Largemouth bass have been plagued by diseases elicited by bacteria, parasites, and viruses, particularly viral diseases, which have caused significant economic losses in recent years. And there is a lack of approved antiviral drugs in the aquaculture industry. Micropterus salmoides Rhabdovirus (MSRV) is the causative agent of Micropterus salmoides Rhabdovirus disease, which mostly affects largemouth bass fry. By using experimental infection, transcriptome sequencing, and inhibitor treatment, the inflammatory response mediated by mitogen-activated protein kinase (MAPK), phosphatidylinositol3-kinase (PI3K), and nuclear factor kappa-B (NF-κB) pathways was verified as one of the pathological processes of MSRV infection. Further, Myricetin, arteannuin, naringenin, ursolic acid, andrographolide, and resveratrol were selected to evolute their anti-inflammatory activity based on the promoter of NF-κB and found myricetin, naringenin, andrographolide, and resveratrol significantly inhibited NF-κB 1 promoter activity. Myricetin was found to damp MSRV caused-inflammation and inhibit MSRV infection by suppressing NF-κB signaling. Besides, myricetin improves the survival rate of largemouth bass after MSRV infection. In conclusion, myricetin presented anti-MSRV activity by targeting the NF-κB inflammatory pathway and can be further developed as a potential preventative drug of rhabdovirus disease.
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来源期刊
Aquaculture and Fisheries
Aquaculture and Fisheries Agricultural and Biological Sciences-Aquatic Science
CiteScore
7.50
自引率
0.00%
发文量
54
审稿时长
48 days
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