用于心肌细胞纤维生长的纳米印迹分层微/纳米结构基质

Q1 Engineering

Nanomanufacturing and Metrology Pub Date : 2023-11-07 DOI:10.3390/nanomanufacturing3040026

Michael M. Mühlberger, Sonja Kopp, Alision A. Deyett, Markus Pribyl, Michael J. Haslinger, Anica M. Siegel, Philipp Taus, Elena Guillén, Aranxa Torres-Caballero, Bozhidar Baltov, Michael A. Netzer, Sonia Prado-López, Leif Yde, Jan Stensborg, Sasha Mendjan, Steffen Hering, Heinz D. Wanzenboeck

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引用次数: 1

摘要

研究心肌细胞的行为是药物开发的重要组成部分。我们提出了一种结构和相关的基于纳米印迹的制造方法，其中心肌细胞形成分离的纤维，这有利于药物测试，更接近地代表体内心肌细胞的结构。我们发现，具有粗糙表面壁的通道结构可以刺激心肌细胞形成所需的纤维。纳米压印光刻技术是一种快速、经济的方法，可用于制造分层结构的细胞生长基质。

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Nanoimprinted Hierarchical Micro-/Nanostructured Substrates for the Growth of Cardiomyocyte Fibers

Investigating the behavior of cardiomyocytes is an important part of drug development. We present a structure and a related nanoimprint-based fabrication method, where the cardiomyocytes form isolated fibers, which is beneficial for drug testing, more closely representing the structure of the cardiomyocytes in vivo. We found that channel structures with walls with a rough top surface stimulate cardiomyocytes to form such fibers, as desired. Nanoimprint lithography is used as a fast and cost-efficient method to fabricate our hierarchically structured cell growth substrates.

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来源期刊

Nanomanufacturing and Metrology Materials Science-Materials Science (miscellaneous)

CiteScore

5.40

自引率

0.00%

发文量

期刊介绍： Nanomanufacturing and Metrology is a peer-reviewed, international and interdisciplinary research journal and is the first journal over the world that provides a principal forum for nano-manufacturing and nano-metrology.Nanomanufacturing and Metrology publishes in the forms including original articles, cutting-edge communications, timely review papers, technical reports, and case studies. Special issues devoted to developments in important topics in nano-manufacturing and metrology will be published periodically.Nanomanufacturing and Metrology publishes articles that focus on, but are not limited to, the following areas:• Nano-manufacturing and metrology• Atomic manufacturing and metrology• Micro-manufacturing and metrology• Physics, chemistry, and materials in micro-manufacturing, nano-manufacturing, and atomic manufacturing• Tools and processes for micro-manufacturing, nano-manufacturing and atomic manufacturing