钙离子驱动水凝胶支架制备抗氧化抗癌生物材料

IF 2.9 4区医学 Q1 Medicine

Journal of biomedical nanotechnology Pub Date : 2023-09-01 DOI:10.1166/jbn.2023.3661

Trung Hieu Le, My Uyen Dao, Thi Hong Chuong Nguyen, Thi Van Thi Tran, Lam Son Le, Thi Nhu Nguyen, Thanh Minh Tran, Hoang Luong Ngoc Nguyen, Xuan Anh Vu Ho

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引用次数: 0

摘要

本研究试图揭示利用钙离子(即ca2 +)作为交联剂制备葡甘露聚糖/胶原基水凝胶的新方法。所获得的复合材料为没食子酸作为活性物质的沉积提供了合适的支架。结果表明，没食子酸修饰的葡甘露聚糖/ ca2 + /胶原复合物(表示为KGM/ ca2 + /Col/GA)在抗氧化试验中表现出较强的抗自由基能力。令人印象深刻的是，生成的KGM/ ca2 + /Col/GA样品在细胞毒性评估中显示出强大的抑制KB细胞的能力，并且具有极低的ic50值(例如8.8±0.5 μ g/mL)。这些证据表明KGM/Ca/Col/GA水凝胶材料在医疗应用中的潜在应用。

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Calcium Ions-Driven Hydrogel Scaffold Toward the Robust Antioxidant and Anticancer Biomaterials

The presented investigation attempts to unveil the novel approach to prepare glucomannan/collagen-based hydrogel through the utilization of calcium ions (i.e., Ca 2+ ) as the cross-linker. The achieved composite provides an appropriate scaffold for the deposition of gallic acid as an active species. It turns out that gallic acid-decorated glucomannan/Ca 2+ /collagen composite (denoted as KGM/Ca 2+ /Col/GA) shows a great capacity to prevent free radicals in the antioxidant test. Impressively, the as-generated KGM/Ca 2+ /Col/GA sample demonstrates a robust capability to inhibit KB cells in the cytotoxic evaluation, associated with an extremely low IC 50 value (e.g., 8.8±0.5 μ g/mL). Such pieces of evidence suggest the potential application of KGM/Ca/Col/GA hydrogel material in medical applications.

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