2-芳基氮唑-3-乙酸衍生物所有区域异构体的合成

IF 2.2 4区化学 Q2 CHEMISTRY, ORGANIC

Synthesis-Stuttgart Pub Date : 2023-11-08 DOI:10.1055/a-2206-5900

Taewook Kim, Ju Hyeon Park, Cheol Jeong, Eunjoon Park, Jong Mu Kim, You-Jin Kim, Jung-Nyoung Heo, Cheol-Hong Cheon

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引用次数: 0

摘要

建立了以2-氨基氮唑酸衍生物和芳基醛为原料，通过亚胺- stetter反应合成2-芳基取代氮唑哚-3-乙酸衍生物的新工艺。2-氨基氮唑酸衍生物与醛缩合形成相应的醛胺，然后用氰化物处理得到所需的2-芳基取代氮唑哚-3-乙酸衍生物。值得注意的是，通过使用合适的氮唑酸衍生物，该方法可用于合成氮唑多-3-乙酸衍生物的所有区域异构体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of All Regioisomers of 2-Aryl Azaindole-3-acetic Acid Derivatives

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Synthesis of All Regioisomers of 2-Aryl Azaindole-3-acetic Acid Derivatives

A novel protocol was developed for synthesizing 2-aryl substituted azaindole-3-acetic acid derivatives from 2-aminoazacinnamic acid derivatives and aryl aldehydes through an imino-Stetter reaction. Condensation of 2-aminoazacinnamic acid derivatives with aldehydes forms the corresponding aldimines, which are then treated with cyanide to yield the desired 2-aryl substituted azaindole-3-acetic acid derivatives. Notably, this protocol could be employed for the synthesis of all regioisomers of azaindole-3-acetic acid derivatives by using the appropriate azacinnamic acid derivatives.

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来源期刊

Synthesis-Stuttgart 化学-有机化学

CiteScore

4.50

自引率

7.70%

发文量

435

审稿时长

1 months

期刊介绍： SYNTHESIS is an international full-paper journal devoted to the advancement of the science of chemical synthesis. It covers all fields of organic chemistry involving synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines. SYNTHESIS provides dependable research results with detailed and reliable experimental procedures and full characterization of all important new products as well as scientific primary data.