Effects of Irrigants on Pulp Stem Cells: A Systematic Review

Endodontic intervention in necrotic immature permanent teeth is usually a clinical challenge. With appropriate case selection, regenerative treatment can be effective, providing a desirable outcome. However, there is still no consensus on the optimal methods to achieve predictable clinical outcome. To ensure a successful regenerative procedure, it is essential to investigate the appropriate disinfection protocols and the use of biocompatible molecules in order to control the release of growth factors and the differentiation of stem cells. This systematic review summarizes the present knowledge regarding the effect of intracanal irrigants on the dental derived stem cells fate in regenerative endodontic procedures. Keywords: Chlorhexidine; Growth factors; Intracanal irrigants; NaOCl; Regenerative endodontics;