河羊肚菌α-葡萄糖苷酶抑制脂肪酸

IF 2.2 4区 农林科学 Q2 HORTICULTURE
Ayman Turk, Solip Lee, Hak Hyun Lee, Sang Won Yeon, Se Hwan Ryu, Geum Hee Seo, Hyun You Chang, Bang Yeon Hwang, Mi Kyeong Lee
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引用次数: 0

摘要

摘要羊肚菌(Morchella fluvialis)是一种羊肚菌,是世界上最著名的食用菌之一。由于其感官特性和营养价值,人们对这种蘑菇的兴趣正在稳步增加。在测定系统中,江茅甲醇提取物具有α-葡萄糖苷酶抑制和抗氧化活性。因此,进行了生物活性代谢物的纯化、表征和生物活性评价。分离得到9个化合物,即3种脂肪酸,(9z, 12z)-十八烯二烯酸(亚油酸,1)、(9z, 12z)-3-羟基十八烯二烯酸(2)和(6z, 9z)-13-羟基十八烯二烯酸(3);四种甾醇,星甾醇(4),麦角甾醇过氧化(5),麦角甾醇(6)和油菜甾醇(7);一种糖醇,阿拉伯糖醇(8);其中化合物2 ~ 3和7为首次从羊肚菌中分离得到。化合物1具有较强的α-葡萄糖苷酶抑制作用,IC 50值为14.8 μM。高效液相色谱法测定其主要化合物化合物1的含量为1.2 mg·g -1提取物,低于化合物1的ic50值。因此,河流支原体可以通过亚油酸(1)和其他成分的协同作用对糖尿病及相关疾病有益。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
α-Glucosidase inhibitory fatty acids from Morchella fluvialis mushroom
ABSTRACT Morchella fluvialis , a morel mushroom, is one of the most famous edible mushrooms all over the world. Interest in this mushroom is steadily increasing due to its organoleptic properties and nutritional value. The methanolic extract of M. fluvialis showed α-glucosidase inhibitory and antioxidant activities in an assay system. Therefore, the purification and characterisation of bioactive metabolites and evaluation of biological activity were conducted. Fractionation of the M. fluvialis extract resulted in the isolation of nine compounds, namely, three fatty acids, (9 Z ,12 Z )-octadecadienoic acid (linoleic acid, 1), (9 Z ,12 Z )-3-hydroxyoctadecadienoic acid (2) and (6 Z ,9 Z )-13-hydroxyoctadecadienoic acid (3); four sterols, stellasterol (4), ergosterol peroxide (5), ergosterol (6) and brassicasterol (7); one sugar alcohol, arabitol (8); and nicotinamide (9). Among them, compounds 2–3 and 7 were first reported from Morchella . In addition, compound 1 exhibited potent α-glucosidase inhibition, with an IC 50 value of 14.8 μM. The content of compound 1, the major compound, was 1.2 mg · g –1 extract, as quantitated by HPLC analysis, which was lower than the IC 50 value of compound 1. Therefore, M. fluvialis can benefit from diabetes and related diseases through the synergistic effect of linoleic acid (1) and other ingredients.
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来源期刊
Folia Horticulturae
Folia Horticulturae Agricultural and Biological Sciences-Horticulture
CiteScore
3.40
自引率
0.00%
发文量
13
审稿时长
16 weeks
期刊介绍: Folia Horticulturae is an international, scientific journal published in English. It covers a broad research spectrum of aspects related to horticultural science that are of interest to a wide scientific community and have an impact on progress in both basic and applied research carried out with the use of horticultural crops and their products. The journal’s aim is to disseminate recent findings and serve as a forum for presenting views as well as for discussing important problems and prospects of modern horticulture, particularly in relation to sustainable production of high yield and quality of horticultural products, including their impact on human health.
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