细胞遗传学在慢性淋巴细胞白血病治疗中的应用:来自法语细胞组织(GFCH)的指南

IF 3.2 4区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Current Research in Translational Medicine Pub Date : 2023-10-01 DOI:10.1016/j.retram.2023.103410

Florence Nguyen-Khac , Zsofia Balogh , Jasmine Chauzeix , Lauren Veronese , Elise Chapiro

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引用次数: 0

摘要

染色体异常在慢性淋巴细胞白血病(CLL)中是常见的，并且大多数具有预后价值。除了四种众所周知的异常(13q, 11q和17p缺失，以及12三体)，其他复发性异常与疾病结局和/或耐药性有关。此外，复杂核型最近已成为接受免疫化疗或靶向治疗的患者的预后标志物。在这里，我们通过回顾最新文献并讨论其检测和临床影响来描述CLL和相关疾病(小淋巴细胞淋巴瘤和单克隆b细胞淋巴细胞增多症)中发现的主要染色体异常。最后，我们提供了CLL细胞遗传学评估的技术指南和策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cytogenetics in the management of chronic lymphocytic leukemia: Guidelines from the Groupe Francophone de Cytogénétique Hématologique (GFCH)

Chromosomal abnormalities are frequent in chronic lymphocytic leukemia (CLL), and most have prognostic value. In addition to the four well-known abnormalities (13q, 11q and 17p deletions, and trisomy 12), other recurrent aberrations have been linked to the disease outcome and/or drug resistance. Moreover, the complex karyotype has recently emerged as a prognostic marker for patients undergoing immunochemotherapy or targeted therapies. Here, we describe the main chromosomal abnormalities identified in CLL and related disorders (small lymphocytic lymphoma and monoclonal B-cell lymphocytosis) by reviewing the most recent literature and discussing their detection and clinical impact. Lastly, we provide technical guidelines and a strategy for the cytogenetic assessment of CLL.

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来源期刊

Current Research in Translational Medicine Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology

CiteScore

7.00

自引率

4.90%

发文量

审稿时长

45 days

期刊介绍： Current Research in Translational Medicine is a peer-reviewed journal, publishing worldwide clinical and basic research in the field of hematology, immunology, infectiology, hematopoietic cell transplantation, and cellular and gene therapy. The journal considers for publication English-language editorials, original articles, reviews, and short reports including case-reports. Contributions are intended to draw attention to experimental medicine and translational research. Current Research in Translational Medicine periodically publishes thematic issues and is indexed in all major international databases (2017 Impact Factor is 1.9). Core areas covered in Current Research in Translational Medicine are: Hematology, Immunology, Infectiology, Hematopoietic, Cell Transplantation, Cellular and Gene Therapy.