糖酵解与急性肺损伤:综述

IF 1.9 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Asian Pacific journal of tropical medicine Pub Date : 2023-11-08 DOI:10.4103/1995-7645.388388

Yang Yi, Jun Chen, Nan Li, Yue Huang, Jichao Peng, Xiaoran Liu

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引用次数: 0

摘要

急性肺损伤以肺或全身损伤引起的弥漫性肺水肿和持续性低氧血症为特征。这些病理变化被认为与肺泡上皮和血管内皮的损伤、炎症细胞的募集和炎症因子风暴有关。近年来，肺实质细胞和免疫细胞的代谢重编程，特别是糖酵解的改变，已被发现发生在急性肺损伤中。抑制糖酵解可减轻急性肺损伤的严重程度。因此，本文就急性肺损伤与糖酵解的相互关系及其相互作用机制进行综述，以期为急性肺损伤的治疗带来希望。

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Glycolysis and acute lung injury: A review

Acute lung injury is featured as diffuse pulmonary edema and persistent hypoxemia caused by lung or systemic injury. It is believed that these pathological changes are associated with damage to the alveolar epithelium and vascular endothelium, recruitment of inflammatory cells, and inflammatory factor storms. In recent years, the metabolic reprogramming of lung parenchymal cells and immune cells, particularly alterations in glycolysis, has been found to occur in acute lung injury. Inhibition of glycolysis can reduce the severity of acute lung injury. Thus, this review focuses on the interconnection between acute lung injury and glycolysis and the mechanisms of interaction, which may bring hope for the treatment of acute lung injury.

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来源期刊

Asian Pacific journal of tropical medicine PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-TROPICAL MEDICINE

CiteScore

4.00

自引率

9.70%

发文量

1936

审稿时长

3-8 weeks

期刊介绍： Asian Pacific Journal of Tropical Medicine (ISSN 1995-7645 CODEN: APJTB6), a publication of Editorial office of Hainan Medical University,is a peer-reviewed print + online Monthly journal. The journal''s full text is available online at http://www.apjtm.org/. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. APJTM aims to provide an academic communicating platform for international physicians, medical scientists, allied health scientists and public health workers, especially those of the Asia-Pacific region and worldwide on tropical medicine, infectious diseases and public health, and to meet the growing challenges of understanding, preventing and controlling the dramatic global emergence and re-emergence of infectious diseases in the Asia-Pacific. The journal is proud to have an international and diverse editorial board that will assist and facilitate the publication of articles that reflect a global view on tropical medicine, infectious diseases and public health, as well as emphasizing our focus on supporting the needs of public health practitioners. The APJTM will allow us to seek opportunities to work with others who share our aim, and to enhance our work through partnership, and to uphold the standards of our profession and contribute to its advancement.