新型吡唑类抗癌药物的多步合成

IF 2.4 3区化学 Q2 CHEMISTRY, ORGANIC

Polycyclic Aromatic Compounds Pub Date : 2024-11-25 DOI:10.1080/10406638.2023.2278664

Amita K. Vyas , Kaushik S. Lunagariya , Ranjan C. Khunt

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引用次数: 0

摘要

摘要吡唑及其衍生物由于具有许多潜在的药理应用而越来越受到人们的关注。合成了一系列新的吡唑杂化化合物(6A-6L)，并用1H NMR、IR和质谱对中间体和终产物进行了表征。筛选吡唑衍生物对NCI-60细胞株的抗癌活性，并将其分为9个不同的亚组。体外抗癌研究表明，化合物6C、6D、6F、6I和6J对肾癌、卵巢癌、黑色素瘤和白血病具有较强的抗癌活性。关键词:吡唑光谱癌症筛选NCI-60细胞系致谢作者感谢Rajkot Saurashtra大学化学系提供的化学和研究实验室设施。SHODH研究奖学金计划。作者感谢CoE-NFDD为光谱数据提供了便利。特别感谢美国国家癌症研究所/国家卫生研究院(NCI-NIH)对合成分子的抗癌测试。披露声明作者未报告潜在的利益冲突。

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Multi-step Synthesis of Novel Pyrazole Derivatives as Anticancer Agents

The attractiveness of pyrazole and its derivatives is increasing because of their numerous potential pharmacological applications. A novel series of pyrazole hybrid compounds (6A–6L) has been synthesized, and all the intermediates and the final products were characterized by 1H NMR, IR, and mass spectrometry. Pyrazole derivatives were screened for their anticancer activity against the NCI-60 cell lines, and grouped into nine different subpanels. In-vitro anticancer studies of the targeted compounds showed that the compounds 6C, 6D, 6F, 6I, and 6J showed potent anticancer activity against renal cancer, ovarian cancer, melanoma, and leukemia cancer.

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来源期刊

Polycyclic Aromatic Compounds 化学-有机化学

CiteScore

3.70

自引率

20.80%

发文量

412

审稿时长

3 months

期刊介绍： The purpose of Polycyclic Aromatic Compounds is to provide an international and interdisciplinary forum for all aspects of research related to polycyclic aromatic compounds (PAC). Topics range from fundamental research in chemistry (including synthetic and theoretical chemistry) and physics (including astrophysics), as well as thermodynamics, spectroscopy, analytical methods, and biology to applied studies in environmental science, biochemistry, toxicology, and industry. Polycyclic Aromatic Compounds has an outstanding Editorial Board and offers a rapid and efficient peer review process, as well as a flexible open access policy.