铝箔辅助ATR-FT-IR光谱检测庆大霉素致大鼠急性肾损伤模型

IF 0.8 4区化学 Q4 SPECTROSCOPY

Spectroscopy Pub Date : 2023-09-01 DOI:10.56530/spectroscopy.ii4190k9

Lujuan Yang, Haoran Fan, Peng Shang, Ying Sun, Wenli Tian, Gang Ma

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引用次数: 0

摘要

傅里叶变换红外光谱(FT-IR)技术多年来在疾病诊断领域备受关注。然而，由于一些瓶颈，FT-IR光谱的临床转化相当缓慢。本研究探讨了铝箔辅助衰减全反射-傅里叶红外光谱(ATR-FT-IR)的潜力，这是一种简单而经济的傅里叶红外采样技术，用于检测庆大霉素诱导的大鼠急性肾损伤(AKI)。结果表明，偏最小二乘判别分析(PLS-DA)能较好地区分大鼠的AKI状态和健康状态。深入讨论了铝箔辅助ATR-FT-IR光谱在基于ft - ir的疾病诊断中的优势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Detection of Acute Kidney Injury Induced by Gentamicin in a Rat Model by Aluminum-Foil-Assisted ATR-FT-IR Spectroscopy

Fourier transform infrared (FT-IR) spectroscopy has attracted great attention in the field of disease diagnostics for many years. Yet, the clinical translation of FT-IR spectroscopy has been rather slow because of several bottlenecks. This work explores the potential of aluminum foil-assisted attenuated total reflectance-FT-IR (ATR-FT-IR) spectroscopy, which is a simple and economical FT-IR sampling technique, to detect acute kidney injury (AKI) induced by gentamicin in a rat model. It was found that partial least squares-discriminant analysis (PLS-DA) could successfully discriminate between the AKI status and the healthy status with the plasma samples of the rats. An in-depth discussion on the advantages of aluminum-foil-assisted ATR-FT-IR spectroscopy in FT-IR-based disease diagnostics is also provided.

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来源期刊

Spectroscopy 物理-光谱学

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Spectroscopy welcomes manuscripts that describe techniques and applications of all forms of spectroscopy and that are of immediate interest to users in industry, academia, and government.