创新治疗增生性皮肤疤痕的复合方法

A. P. Nogerov, L. S. Kruglova, A. G. Stenko, N. E. Manturova
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引用次数: 0

摘要

目前,许多治疗GR的方法缺乏足够的证据基础,而且数据是相互矛盾的,这决定了旨在开发和研究新方法的有效性和安全性的研究的相关性,这些新方法可以影响病理性疤痕的发病机制的主要环节。我们研究的目的是科学地证实和开发一种联合治疗方法,用于持续长达1年的严重增生性疤痕患者,使用钕激光和5-氟尿嘧啶和杜兰特皮质类固醇的肺动力治疗,以研究血流动力学过程为基础。研究组包括34例增生性瘢痕患者,接受GCS和5-FU两种肺动力学治疗,间隔2个月。再过一个月,进行1064nm钕激光治疗。LDF研究的结果证实了关于增生性瘢痕微循环床初始变化的早期结果,以及开发的GCS + 5-FU肺动力治疗方法的高效率和后续使用钕激光(1064 nm)的数据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Innovative complex method of therapy of hypertrophic skin scars
Many methods of therapy for GR are currently insufficiently studied in terms of a high evidence base, and the data are contradictory, which determinesthe relevance of research aimed at developing and studying the effectiveness and safety of new methods that can influence the main links in thepathogenesis of pathological scars. The aim of our study was to scientifically substantiate and develop a combined method of therapy for patients withsevere hypertrophic scars lasting up to 1 year using a neodymium laser and pneumokinetic therapy with 5-fluorouracil and durant corticosteroid basedon a study of hemodynamic processes. The study group included 34 patients with hypertrophic scars who underwent two procedures of pneumokinetictherapy with GCS and 5-FU, with an interval of two months. After another one month, laser therapy with a neodymium laser (1064nm) was performed.The results of the LDF study confirmed the early results obtained on the initial changes in the microcirculatory bed in hypertrophic scars, as well as dataon the high efficiency of the developed method of pneumokinetic therapy of GCS + 5-FU and the sequential use of a neodymium laser (1064 nm).
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