从海洋来源的青霉属真菌中分离出一种抗菌外消旋苯烯酮衍生物

IF 1.1 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Canadian Journal of Chemistry Pub Date : 2023-09-29 DOI:10.1139/cjc-2023-0100

Nicholas Morehouse, Kelsie Graham, Samantha Cox, John Johnson, Christopher Gray

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引用次数: 0

摘要

从海洋来源的青霉属真菌的乙酸乙酯萃取物中分离得到一个新的苯烯酮衍生物2,4,6,9-四羟基-7-甲基-2-戊酰- 1h -苯烯-1,3(2H)-二酮(1)，该化合物具有独特的抗菌活性。通过1D和2D NMR实验确定了1的平面结构，圆二色性和偏振性表明其为对映异构体的外消旋混合物。1对革兰氏阳性和革兰氏阴性细菌和真菌菌株的抑菌活性进行了评估，发现它有选择性地抑制金黄色葡萄球菌和结核分枝杆菌的生长。

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Isolation of an antimicrobial racemic phenalenone derivative from a marine-derived Penicillium sp. fungus

A new phenalenone derivative, 2,4,6,9-tetrahydroxy-7-methyl-2-prenyl-1H-phenalene-1,3(2H)-dione (1), was isolated from the ethyl acetate extract of a marine derived Penicillium sp. fungus that exhibited a unique antimicrobial activity profile. The planar structure of 1 was determined through a combination of 1D and 2D NMR experiments, and circular dichroism and polarimetry indicated that it was isolated as a racemic mixture of enantiomers. The antimicrobial activity of 1 was assessed against a panel of Gram-positive and Gram-negative bacteria and fungal strains and it was found to selectively inhibit the growth of Staphylococcus aureus and Mycobacterium tuberculosis.

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来源期刊

Canadian Journal of Chemistry 化学-化学综合

CiteScore

1.90

自引率

9.10%

发文量

审稿时长

1 months

期刊介绍： Published since 1929, the Canadian Journal of Chemistry reports current research findings in all branches of chemistry. It includes the traditional areas of analytical, inorganic, organic, and physical-theoretical chemistry and newer interdisciplinary areas such as materials science, spectroscopy, chemical physics, and biological, medicinal and environmental chemistry. Articles describing original research are welcomed.