甲氧氯普胺和海莨菪碱-正丁基溴在结肠运动中的作用

Sleman Y. Omar, Dyari M. Mamand, Rebaz A. Omer, Rzgar F. Rashid, Musher I. Salih
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引用次数: 0

摘要

甲氧氯普胺是一种治疗胃肠炎伴呕吐的药物。海莨菪碱-正丁基溴作为一种抗胆碱能剂,通过作用于毒蕈碱受体而抑制乙酰胆碱(Ach)。该研究旨在确定甲氧氯普胺如何影响疼痛引起的皮质运动,并研究甲氧氯普胺单独使用和与海莨菪碱-正丁基溴药物联合使用对结肠运动的影响。在本研究中,切除1 cm的结肠组织宽度,制作2 cm长的条带,在离体器官的离体组织两端用手术丝固定,张力为(1g),悬挂仪器记录等距收缩。组织固定之后是药物成瘾:乙酰胆碱、甲氧氯普胺和海莨菪碱-正丁基溴。组织用甲氧氯普胺和海莨菪碱-正丁基溴和过量卡因处理10分钟。结果显示,甲氧氯普胺、海莨菪碱-正丁基、甲氧氯普胺和海莨菪碱的结肠频率、峰对峰和振幅水平发生了变化。配对t检验对结果进行统计分析。甲氧氯普胺单用以及与海莨菪碱-正丁基溴联用可增加结肠活力并诱导乙酰胆碱释放。此外,还对海莨菪碱-正丁基溴和甲氧氯普胺分子的理化性质进行了分析。该研究包括在气体和水环境中质子化和非质子化形式的这些分子的电子参数的理论计算。这些结果表明甲氧氯普胺作为胃肠炎伴呕吐的潜在治疗选择,需要进一步的研究和临床评估。研究还揭示了海莨菪碱-正丁基溴和甲氧氯普胺的理化性质。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Investigating the Role of Metoclopramide and Hyoscine-N-Butyl Bromide in Colon Motility
Metoclopramide is a treatment for gastroenteritis accompanied by vomiting. Hyoscine-n-butyl bromide as an anticholinergic agent causes inhibition of the acetylcholine (Ach) by acting on muscarinic receptors. The study aims to ascertain how metoclopramide affects Ach-induced cortical motility and also investigates the effects of metoclopramide alone and in combination with hyoscine-n-butyl bromide drug effects on colon motility. In this study, 1 cm of colon tissue width was cut, 2 cm long strips were made, and both sides of the tissue were secured with surgical silk at both ends of isolated bath tissues of isolated organs with (1g) tension to the suspended instrument that recorded isometric contractions. Tissue fixation is followed by drug addiction: Ach, metoclopramide, and hyoscine-N-butyl bromide. The tissue was treated with metoclopramide and hyoscine-n-butyl bromide and excess Caine for 10 min. The results show changes in colon frequency, peak-to-peak, and amplitude levels for metoclopramide, hyoscine-N-butyl, and metoclopramide and hyoscine. Apaired T-test statistically analyzes the results. Metoclopramide by itself, as well as in combination with hyoscine-n-butyl bromide, increases colon motility and induces Ach release. In addition, an analysis of the physicochemical characteristics of hyoscine-n-butyl bromide and metoclopramide molecules is conducted. The study includes theoretical calculations of electronic parameters for both protonated and unprotonated forms of these molecules in both gaseous and aqueous environments. These results show the potential use of metoclopramide as a therapeutic option for gastroenteritis with vomiting, warranting additional study, and clinical evaluation. The research also reveals hyoscine-n-butyl bromide and metoclopramide’s molecular features by their physicochemical properties.
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