维生素D:自身免疫、代谢和微生物模型中炎症的遗传调控

E. V. Loshkova, E. I. Kondratyeva, A. I. Khavkin, E. K. Zhekaite, Yu. V. Kotova, Yu. L. Melyanovskaya, M. I. Erokhina, E. A. Yablokova, V. A. Zhelev
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引用次数: 0

摘要

细胞因子的产生及其在儿童各种发病机制疾病中的遗传调控的研究,其中包括几种炎症机制——这是针对乳糜泻、1型糖尿病和CAI背景的自身免疫性疾病,针对血液肿瘤疾病背景的淋巴细胞增生性疾病,以慢性肾盂肾炎和囊性纤维化为背景的微生物炎症和以肥胖和骨密度降低为背景的代谢,对于扩大对发病机制的理解、预测疾病临床病程(临床表型)和并发症的变异以及对治疗的反应是必要的。文献综述致力于分析和解释维生素D供应及其遗传调控对疾病进程的影响,根据炎症的主要发病机制结合自身免疫、微生物和淋巴细胞增生性模型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Vitamin D: genetic regulation of inflammation in autoimmune, metabolic and microbial models
The study of cytokine production and its genetic regulation in diseases of various pathogenesis in childhood, which include several mechanisms of inflammation - this is autoimmune against the background of celiac disease, type 1 diabetes and CAI, lymphoproliferative against the background of oncohematological diseases, microbial-inflammatory against the background of chronic pyelonephritis and cystic fibrosis and metabolic against the background of obesity and a decrease in bone mineral density is necessary to expand understanding of pathogenesis, predict variants of the clinical course of diseases (clinical phenotypes) and complications, as well as response to therapy. The literature review is devoted to the analysis and interpretation of data on the effect of vitamin D supply and its genetic regulation on the course of diseases, combined according to the leading pathogenetic mechanism of inflammation into autoimmune, microbial, and lymphoproliferative models.
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