以樟脑为原料合成具有生物活性的杂蒽、铬烯、噻唑、噻吩、吡唑和异恶唑衍生物

IF 1.3 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Bulletin of the Chemical Society of Ethiopia Pub Date : 2023-09-19 DOI:10.4314/bcse.v37i6.18

Ensaf Sultan Alwan, Rafat Milad Mohareb

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引用次数: 0

摘要

摘要以樟脑- d单萜为原料，采用多组分反应合成了杂蒽、铬烯、噻唑、噻吩、吡唑和异恶唑衍生物。樟脑具有抗菌、抗真菌和抗炎的特性。它也被用来减轻疼痛，治疗皮肤病，改善呼吸功能。在本研究中，我们重点研究了从生物活性樟脑中提取的化合物的有效性。所生成的化合物是根据各种反应形成的，如Knoevenagel缩合、Michael加合、Gewald反应、亲核攻击、取代、加成、消除和环化反应。此外，新合成的化合物已对A549、MKN-45、U87MG、HT-29、H460和SMMC-772 6种癌细胞系进行了测试。化合物5、11、15b、16、25b和27b对上述肿瘤细胞系的抑制作用最强。此外，化合物3、13、15a、22a、27a和28对癌细胞具有中等抑制作用。关键词:樟脑，杂蒽，嘧啶，杂环，抗癌;公牛。化学。Soc。中国生物医学工程学报，2016,37(6):1539-1552。DOI: https://dx.doi.org/10.4314/bcse.v37i6.18

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Synthesis of biologically active xanthene, chromene, thiazole, thiophene, pyrazole, and isoxazole derivatives from camphor

ABSTRACT. Xanthene, chromene, thiazole, thiophene, pyrazole, and isoxazole derivatives were synthesized from camphor-D monoterpene using multi-component reactions. Camphor has anti-bacterial, anti-fungal and anti-inflammatory properties. It is also used to mitigate pain, treat skin diseases, and improve respiratory functions. In this research, we focus on the effectiveness of the produced compounds from the biologically active camphor. The produced compounds were formed according to various reactions such as a Knoevenagel condensation, Michael adduct, Gewald reaction, a nucleophilic attack, substitution, addition, elimination and cyclization reactions. Furthermore, the novel produced compounds have been tested towards the six cancer cell lines namely A549, MKN-45, U87MG, HT-29, H460 and SMMC-772. Compounds 5, 11, 15b, 16, 25b and 27b displayed the highest inhibitions compounds toward the mentioned cancer cell lines. In addition, compounds 3, 13, 15a, 22a, 27a and 28 showed moderate inhibitory effects against the cancer cell lines. KEY WORDS: Camphor, Xanthenes, Pyrimidine, Heterocyclic, Anti-cancer Bull. Chem. Soc. Ethiop. 2023, 37(6), 1539-1552. DOI: https://dx.doi.org/10.4314/bcse.v37i6.18

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来源期刊

Bulletin of the Chemical Society of Ethiopia 化学-化学综合

CiteScore

2.20

自引率

8.30%

发文量

113

审稿时长

6-12 weeks

期刊介绍： The Bulletin of the Chemical Society of Ethiopia (BCSE) is a triannual publication of the Chemical Society of Ethiopia. The BCSE is an open access and peer reviewed journal. The BCSE invites contributions in any field of basic and applied chemistry.