罗勒提取物在神经退行性大鼠模型中调节Tau聚集并改善记忆功能

Q3 Biochemistry, Genetics and Molecular Biology
Mrwa Shalan, Layla Alhasan
{"title":"罗勒提取物在神经退行性大鼠模型中调节Tau聚集并改善记忆功能","authors":"Mrwa Shalan, Layla Alhasan","doi":"10.5455/jabet.2023.d162","DOIUrl":null,"url":null,"abstract":"The main objective of this study was evaluation of the neuroprotective potential effect of Ocimum basilicum on oxidative stress status in rat induced Alzheimer's disease. Fifty rats were divided into five groups (ten rats each). Rats were treated orally with AlCl3 to induced AD. Group 1 (control group). Group 2 (AD group): supplemented orally with AlCl3 (17mg/kg/day) for four weeks. Group 3 (OB/AD group) supplemented concomitantly with oral rivastigmine (3 mg/kg /day). Group 4 (OB/AD group) supplemented concomitantly with oral OB (250mg/kg/day) and Group 5 (OB/AD group) supplemented concomitantly with oral OB (500 mg/kg/day). The results showed that the plant leaves extract increased serum superoxide dismutase (SOD) with a significant decrease of a serum MDA and also the aggregation of tau protein expression was decreased . Histological changes were observed in brain tissues of AD rats. However, the high dosing of the plant leaves extract (500 mg/kg) was more powerful than the low treatment with low dose (250 mg/kg) by decreasing Tau protein expression. The results suggest that Ocimum basilicum can relieve symptoms and prevent the progression of AD severity by improving memory function. It can be concluded that OB leaves were alleviated the memory impairment and learning abilities due to antioxidants activity of flavonoids, tannins and terpenoids.","PeriodicalId":36275,"journal":{"name":"Journal of Advanced Biotechnology and Experimental Therapeutics","volume":"37 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ocimum basilicum extract modulates Tau aggregation and improves memory function in a neurodegenerative rat model\",\"authors\":\"Mrwa Shalan, Layla Alhasan\",\"doi\":\"10.5455/jabet.2023.d162\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The main objective of this study was evaluation of the neuroprotective potential effect of Ocimum basilicum on oxidative stress status in rat induced Alzheimer's disease. Fifty rats were divided into five groups (ten rats each). Rats were treated orally with AlCl3 to induced AD. Group 1 (control group). Group 2 (AD group): supplemented orally with AlCl3 (17mg/kg/day) for four weeks. Group 3 (OB/AD group) supplemented concomitantly with oral rivastigmine (3 mg/kg /day). Group 4 (OB/AD group) supplemented concomitantly with oral OB (250mg/kg/day) and Group 5 (OB/AD group) supplemented concomitantly with oral OB (500 mg/kg/day). The results showed that the plant leaves extract increased serum superoxide dismutase (SOD) with a significant decrease of a serum MDA and also the aggregation of tau protein expression was decreased . Histological changes were observed in brain tissues of AD rats. However, the high dosing of the plant leaves extract (500 mg/kg) was more powerful than the low treatment with low dose (250 mg/kg) by decreasing Tau protein expression. The results suggest that Ocimum basilicum can relieve symptoms and prevent the progression of AD severity by improving memory function. It can be concluded that OB leaves were alleviated the memory impairment and learning abilities due to antioxidants activity of flavonoids, tannins and terpenoids.\",\"PeriodicalId\":36275,\"journal\":{\"name\":\"Journal of Advanced Biotechnology and Experimental Therapeutics\",\"volume\":\"37 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Advanced Biotechnology and Experimental Therapeutics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5455/jabet.2023.d162\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Advanced Biotechnology and Experimental Therapeutics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5455/jabet.2023.d162","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0

摘要

本研究的主要目的是评价罗勒对大鼠阿尔茨海默病氧化应激状态的潜在神经保护作用。50只大鼠分为5组(每组10只)。大鼠口服AlCl3诱导AD。第一组(对照组)。第二组(AD组):口服AlCl3 (17mg/kg/d),持续4周。第三组(OB/AD组)在对照组的基础上,口服利瓦斯汀(3mg /kg /d)。4组(OB/AD组)联合口服OB (250mg/kg/d), 5组(OB/AD组)联合口服OB (500mg /kg/d)。结果表明,植物叶提取物提高了血清超氧化物歧化酶(SOD),显著降低了血清丙二醛(MDA),降低了tau蛋白的聚集表达。阿尔茨海默病大鼠脑组织组织学改变。然而,高剂量的植物叶片提取物(500 mg/kg)通过降低Tau蛋白表达比低剂量的低剂量处理(250 mg/kg)更有效。结果提示,罗勒可通过改善记忆功能,缓解AD症状,防止病情恶化。综上所述,OB叶中黄酮类、单宁类和萜类化合物具有抗氧化活性,从而减轻了小鼠的记忆障碍和学习能力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ocimum basilicum extract modulates Tau aggregation and improves memory function in a neurodegenerative rat model
The main objective of this study was evaluation of the neuroprotective potential effect of Ocimum basilicum on oxidative stress status in rat induced Alzheimer's disease. Fifty rats were divided into five groups (ten rats each). Rats were treated orally with AlCl3 to induced AD. Group 1 (control group). Group 2 (AD group): supplemented orally with AlCl3 (17mg/kg/day) for four weeks. Group 3 (OB/AD group) supplemented concomitantly with oral rivastigmine (3 mg/kg /day). Group 4 (OB/AD group) supplemented concomitantly with oral OB (250mg/kg/day) and Group 5 (OB/AD group) supplemented concomitantly with oral OB (500 mg/kg/day). The results showed that the plant leaves extract increased serum superoxide dismutase (SOD) with a significant decrease of a serum MDA and also the aggregation of tau protein expression was decreased . Histological changes were observed in brain tissues of AD rats. However, the high dosing of the plant leaves extract (500 mg/kg) was more powerful than the low treatment with low dose (250 mg/kg) by decreasing Tau protein expression. The results suggest that Ocimum basilicum can relieve symptoms and prevent the progression of AD severity by improving memory function. It can be concluded that OB leaves were alleviated the memory impairment and learning abilities due to antioxidants activity of flavonoids, tannins and terpenoids.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of Advanced Biotechnology and Experimental Therapeutics
Journal of Advanced Biotechnology and Experimental Therapeutics Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
1.90
自引率
0.00%
发文量
41
审稿时长
8 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信