Mahoni种子提取物体内外抗糖尿病实验研究Jacq)

Q3 Pharmacology, Toxicology and Pharmaceutics

Biomedical and Pharmacology Journal Pub Date : 2023-09-30 DOI:10.13005/bpj/2748

Aktsar Roskiana Ahamd, Abd. Malik, Virsa Handayani

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引用次数: 0

摘要

这项研究考察了马霍尼种子作为治疗糖尿病的药物的前景。红木种子先用正己烷洗涤，再用乙醇洗涤。提取液采用标准分光光度计，用阿卡波糖(glucobay)测定。在四氧嘧啶刺激小鼠中测试葡萄糖耐量。结果表明，该提取物对a-葡萄糖苷酶具有非竞争性抑制作用。120和240 mg/kg剂量下，提取物的IC50值为4.7 μg/ml，低于阿卡波糖的IC50值5.7 μg/ml，对糖耐量的影响较小。综上所述，纯化红木籽提取物具有开发新型抗糖尿病药物的潜力。

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In Vivo and In Vitro Antidiabetic Assay of Purified Mahoni Seeds Extract (Swietenia mahagoni (L.) Jacq)

This study examined the future of Mahoni seed as an aspirant drug for treating diabetes. Mahogany seeds were washed using n-hexane solvent and followed by ethanol solvent. Extracts were measured using a standard spectrophotometric plate reader with acarbose (Glucobayâ). Glucose tolerance was tested in alloxan-challenged mice. The results indicated that the extract had potency against a-glucosidases inhibited through a non-competitive mechanism. The IC50 value of the extract is 4.7 μg/ml, which was lower than 5.7 μg/ml for acarbose and has less activity on glucose tolerance at doses of 120 and 240 mg/kg. As a conclution, purified mahogany seed extract got the ability to be developed as a new antidiabetic drug candidate.

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来源期刊

Biomedical and Pharmacology Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

1.20

自引率

0.00%

发文量

189

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