增强壳聚糖凝胶对食管黏膜的保护作用

IF 0.8 Q4 MATERIALS SCIENCE, BIOMATERIALS

Progress on Chemistry and Application of Chitin and its Derivatives Pub Date : 2023-09-30 DOI:10.15259/pcacd.28.010

Katarzyna Małolepsza-Jarmołowska

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引用次数: 0

摘要

胃食管反流病的症状对患者来说是一个严重的健康、医学和社会问题。主要的问题是胃食管反酸。在这项研究中，我研究了可以防止食管粘膜破坏的水凝胶。研究了壳聚糖和poloxam407对凝胶保护性能的影响。壳聚糖的加入提高了凝胶的pH值和动态粘度。含25%波洛沙姆407的制剂ph值最高。织构试验表明，波洛沙姆浓度对所测凝胶的粘附性能有影响。研究结果表明，这种凝胶可用于治疗晚期胃酸反流。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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INCREASING THE EFFECTIVENESS OF CHITOSAN GELS TO PROTECT THE OESOPHAGEAL MUCOSA

The troublesome symptoms of gastro-oesophageal reflux disease are a serious health, medical, and social problem for patients. The main problem is gastro-oesophageal acid reflux. In this study, I investigated hydrogels that could prevent the destruction of the oesophageal mucosa. I investigated the effect of chitosan and poloxamer 407 on the protective properties of gels. The addition of chitosan to all the tested gels increased their pH and dynamic viscosity. Preparations containing 25% poloxamer 407 showed the highest pH. Texture tests showed the effect of the poloxamer concentration on the adhesion performance of the tested gels. The findings suggest that the gels can be used to treat advanced acid reflux.

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来源期刊

Progress on Chemistry and Application of Chitin and its Derivatives MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

1.10

自引率

16.70%

发文量

期刊介绍： Progress in the Chemistry and Application of Chitin and its Derivatives is an annual journal focused on all aspects of production, modification, enzymology and application of chitin and its many derivatives, including chitosan. The journal publishes full-length papers as well as invited reviews. To be considered, papers must present original research that has not been published or accepted for publication elsewhere. The language of the journal will be English.