壳聚糖凝胶预防反流病

IF 0.8 Q4 MATERIALS SCIENCE, BIOMATERIALS

Progress on Chemistry and Application of Chitin and its Derivatives Pub Date : 2023-09-30 DOI:10.15259/pcacd.28.009

Katarzyna Małolepsza-Jarmołowska

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引用次数: 0

摘要

反流病是发达国家最常诊断的疾病之一。问题在于胃的酸性和肠道的碱性。在每一种情况下，食管粘膜都被破坏。我分析了防止刺激食管粘膜的水凝胶。具体来说，我研究了壳聚糖和海藻酸钠对凝胶保护食道性能的影响。含有壳聚糖和1.0%海藻酸钠的凝胶可用于治疗晚期碱性反流。在所有测试凝胶中添加壳聚糖增加了它们的pH值和动态粘度，从而可以中和酸反流。结构研究表明壳聚糖和海藻酸钠对凝胶的粘附性有影响。

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CHITOSAN GELS TO PREVENT REFLUX DISEASE

Reflux disease is one of the most frequently diagnosed conditions in developed countries. The problem is both the acidic content of the stomach and the alkaline content of the intestines. In each case, the oesophageal mucosa is destroyed. I analysed hydrogels that prevent irritation of the oesophageal mucosa. Specifically, I investigated the effect of chitosan and sodium alginate on the properties of gels protecting the oesophagus. Gels containing chitosan and 1.0% sodium alginate can be used to treat advanced alkaline reflux. The addition of chitosan to all the tested gels increased their pH and dynamic viscosity, making it possible to neutralise acid reflux. Texture studies showed the influence of chitosan and sodium alginate on the adhesiveness of the tested gels.

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来源期刊

Progress on Chemistry and Application of Chitin and its Derivatives MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

1.10

自引率

16.70%

发文量

期刊介绍： Progress in the Chemistry and Application of Chitin and its Derivatives is an annual journal focused on all aspects of production, modification, enzymology and application of chitin and its many derivatives, including chitosan. The journal publishes full-length papers as well as invited reviews. To be considered, papers must present original research that has not been published or accepted for publication elsewhere. The language of the journal will be English.