分泌性猫传染性腹膜炎猫回肠中FIPV3-70抗原表达的免疫组化研究

IF 0.7 4区 农林科学 Q3 VETERINARY SCIENCES
Todor Novakov, Ivica Gjurovski, Spiro Bozinoski, Aleksandar Janevski, Elena Atanaskova Petrov, Slavica Kostadinova Kunovska, Trpe Ristoski
{"title":"分泌性猫传染性腹膜炎猫回肠中FIPV3-70抗原表达的免疫组化研究","authors":"Todor Novakov, Ivica Gjurovski, Spiro Bozinoski, Aleksandar Janevski, Elena Atanaskova Petrov, Slavica Kostadinova Kunovska, Trpe Ristoski","doi":"10.2478/acve-2023-0032","DOIUrl":null,"url":null,"abstract":"Abstract One of the most common infectious causes of cat mortality is feline infective peritonitis (FIP), along with panleukopenia and viral upper respiratory tract infections. FIP is more likely to affect cats whose immune system is weak or suppressed. It is thought that the infection of macrophages and monocytes plays a major role in the pathogenic process. In order to set a definitive diagnosis for this infectious disease, a histopathological examination of tissues, and feline coronavirus (FCoV) detection by immunohistochemistry (IHC) is necessary. In this investigation, 15 cats between the ages of 5 and 24 months with clinical suspicion of FIP, underwent post-mortem necropsy, pathohistological and immunohistochemical examination. The results showed that all the cats had abdominal effusion with pyogranulomas throughout the abdominal serosa. Ten out of fifteen cats were FIP positive using immunohistochemical methods. This method also showed the antigen deposition in the macrophages thus confirming their role in the pathogenesis of FIP.","PeriodicalId":55559,"journal":{"name":"Acta Veterinaria-Beograd","volume":"26 1","pages":"0"},"PeriodicalIF":0.7000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Immunohistochemical investigation of FIPV3-70 antigen expression in the ileum of cats with effusive feline infective peritonitis\",\"authors\":\"Todor Novakov, Ivica Gjurovski, Spiro Bozinoski, Aleksandar Janevski, Elena Atanaskova Petrov, Slavica Kostadinova Kunovska, Trpe Ristoski\",\"doi\":\"10.2478/acve-2023-0032\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract One of the most common infectious causes of cat mortality is feline infective peritonitis (FIP), along with panleukopenia and viral upper respiratory tract infections. FIP is more likely to affect cats whose immune system is weak or suppressed. It is thought that the infection of macrophages and monocytes plays a major role in the pathogenic process. In order to set a definitive diagnosis for this infectious disease, a histopathological examination of tissues, and feline coronavirus (FCoV) detection by immunohistochemistry (IHC) is necessary. In this investigation, 15 cats between the ages of 5 and 24 months with clinical suspicion of FIP, underwent post-mortem necropsy, pathohistological and immunohistochemical examination. The results showed that all the cats had abdominal effusion with pyogranulomas throughout the abdominal serosa. Ten out of fifteen cats were FIP positive using immunohistochemical methods. This method also showed the antigen deposition in the macrophages thus confirming their role in the pathogenesis of FIP.\",\"PeriodicalId\":55559,\"journal\":{\"name\":\"Acta Veterinaria-Beograd\",\"volume\":\"26 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta Veterinaria-Beograd\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2478/acve-2023-0032\",\"RegionNum\":4,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Veterinaria-Beograd","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2478/acve-2023-0032","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
引用次数: 0

摘要

猫感染性腹膜炎(FIP)是猫死亡最常见的感染性原因之一,同时伴有泛白细胞减少症和病毒性上呼吸道感染。FIP更容易影响免疫系统较弱或受到抑制的猫。据认为,巨噬细胞和单核细胞的感染在致病过程中起主要作用。为了对这种传染病做出明确的诊断,需要对组织进行组织病理学检查,并通过免疫组织化学(IHC)检测猫冠状病毒(FCoV)。在这项研究中,15只年龄在5至24个月之间,临床怀疑患有FIP的猫进行了尸检、病理组织学和免疫组织化学检查。结果显示,所有猫腹腔积液伴脓肉芽肿遍布腹腔浆膜。免疫组化法15只猫中有10只呈FIP阳性。该方法还显示了抗原在巨噬细胞中的沉积,从而证实了它们在FIP发病机制中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Immunohistochemical investigation of FIPV3-70 antigen expression in the ileum of cats with effusive feline infective peritonitis
Abstract One of the most common infectious causes of cat mortality is feline infective peritonitis (FIP), along with panleukopenia and viral upper respiratory tract infections. FIP is more likely to affect cats whose immune system is weak or suppressed. It is thought that the infection of macrophages and monocytes plays a major role in the pathogenic process. In order to set a definitive diagnosis for this infectious disease, a histopathological examination of tissues, and feline coronavirus (FCoV) detection by immunohistochemistry (IHC) is necessary. In this investigation, 15 cats between the ages of 5 and 24 months with clinical suspicion of FIP, underwent post-mortem necropsy, pathohistological and immunohistochemical examination. The results showed that all the cats had abdominal effusion with pyogranulomas throughout the abdominal serosa. Ten out of fifteen cats were FIP positive using immunohistochemical methods. This method also showed the antigen deposition in the macrophages thus confirming their role in the pathogenesis of FIP.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Acta Veterinaria-Beograd
Acta Veterinaria-Beograd 农林科学-兽医学
CiteScore
1.30
自引率
16.70%
发文量
33
审稿时长
18-36 weeks
期刊介绍: The Acta Veterinaria is an open access, peer-reviewed scientific journal of the Faculty of Veterinary Medicine, University of Belgrade, Serbia, dedicated to the publication of original research articles, invited review articles, and to limited extent methodology articles and case reports. The journal considers articles on all aspects of veterinary science and medicine, including the diagnosis, prevention and treatment of medical conditions of domestic, companion, farm and wild animals, as well as the biomedical processes that underlie their health.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信