比替格拉韦/恩曲他滨/替诺福韦阿拉非米特治疗癌症和移植受者HIV/乙肝病毒合并感染

IF 4 4区 医学 Q1 INFECTIOUS DISEASES
Jana K Dickter, Justine A Ross
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引用次数: 0

摘要

对于出现合并症需要多种药物治疗的HIV/ HBV合并感染患者,由于药物相互作用和所接受药物的重叠毒性,治疗可能会变得复杂。随着艾滋病毒感染者的年龄增长,越来越多的患者发展为恶性肿瘤并接受移植,治疗变得复杂。这篇综述描述了一个假设的HIV/HBV合并感染患者发展为弥漫性大b细胞淋巴瘤并最终接受自体造血干细胞移植的最佳治疗策略。在这种理论上的情况下,患者接受比替重力韦/恩曲他滨/替诺福韦阿拉胺治疗。艾滋病毒感染者存在潜在的抗逆转录病毒耐药性和乙型肝炎病毒耐药性,需要优化其抗病毒治疗。由于这些类型的病例在我们的机构中很常见,我们讨论了治疗过程中出现的特殊情况,包括免疫重建炎症综合征,需要密切监测和在治疗过程中偶尔修改治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bictegravir/Emtricitabine/Tenofovir Alafenomide for the Treatment of HIV/Hepatitis B Virus Co-infection in Patients with Cancer and Transplant Recipients
For people with HIV/hepatitis B virus (HBV) co-infection who develop comorbidities that require polypharmacy, treatment may be complicated due to drug interactions and overlapping toxicities of medications received. As the population with HIV ages, there are more patients developing malignancies and undergoing transplantation, and management can be complicated. This review describes the best strategies for the treatment of a hypothetical patient with HIV/HBV co-infection who develops diffuse large B-cell lymphoma and ultimately undergoes autologous haematopoietic stem cell transplantation. In this theoretical case, the patient is treated with bictegravir/emtricitabine/tenofovir alafenamide. Situations arise where people with HIV have underlying antiretroviral drug resistance and HBV drug resistance that require optimization of their antiviral therapy. As these types of cases are seen commonly at our institution, we discuss special situations that develop during treatment, including immune reconstitution inflammatory syndrome, that require close monitoring and occasional treatment modifications during their course of therapy.
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来源期刊
Infectious Diseases
Infectious Diseases INFECTIOUS DISEASES-
CiteScore
8.20
自引率
1.70%
发文量
92
审稿时长
8 weeks
期刊介绍: Infectious Diseases (formerly Scandinavian Journal of Infectious Diseases) is a peer-reviewed journal publishing articles on all aspects of human infection, including pathogenesis, diagnosis, and treatment of infectious diseases, and also on medical microbiology and epidemiology
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