The effect of 8 weeks of combined exercises (aerobic and resistance) along with supplemental consumption of mulberry leaf extract on serum levels of chemerin and pentraxin 3 in elderly men with type 2 diabetes

Introduction: Chemerin and pentraxin 3 are involved in age-related metabolic disorders such as type 2 diabetes. The purpose of this study was to investigate the effect of 8 weeks of combined exercises (aerobic and resistance) along with the consumption of mulberry leaf extract supplement on the serum levels of chemerin and pentraxin 3 in elderly men with type 2 diabetes. Methods: In a clinical trial with a single-blind design, 40 elderly men with type 2 diabetes were randomly assigned to five groups: control, placebo, extract, exercise, and extract + exercise (8 people in each group). The exercises were done for eight weeks and three sessions for 90 minutes. 3000 ml of mulberry leaf extract per day was prescribed along with three main meals. Camerin and pentraxin 3 values were measured before the intervention and 48 hours after the last training session. Results: In the exercise, extract and exercise+extract groups, a significant decrease in the levels of chemerin (4/33%) and glucose (12/9%) and a significant increase in pentraxin 3 (4/12%) were observed (P<0/05). The results between groups showed a significant difference in the level of glucose (P=0/001), Chemerin (P=0/001) and Pentraxin 3 (P=0/001) and these changes in the extract + training group compared to the training groups And the extract isbigger. Conclusion: It seems that the administration of a combined program along with the consumption of mulberry leaf extract in diabetic elderly can have a positive effect on the improvement of cardiovascular inflammatory indicators affecting type 2 diabetes.