[几种n -乙烯基吡咯烷酮co(ter)聚合物对C3HA小鼠肝癌22a的抗肿瘤和免疫刺激作用]。

Eksperimental'naia onkologiia Pub Date : 1990-01-01

T A Korosteleva, K S Movsesian, M V Solovskiĭ, E F Panarin, O V Nazarova, I S Kochetkova

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引用次数: 0

摘要

研究了不同化学结构的水溶性n -乙烯基吡咯烷酮共聚物的抗肿瘤和免疫佐剂作用。结果表明，共聚物n-乙烯基吡咯烷酮(VP)-巴豆酸(CA)- n-巴豆酰胺酚对肝癌22a的生长抑制作用为50 ~ 60%，共聚物VP-CA具有免疫佐剂作用。co(ter)聚合物的这些特性是由于它们的化学结构和分子量，但它们之间并不总是相关的。

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[Antineoplastic and immunostimulating effects of several N-vinylpyrrolidone co(ter)polymers in C3HA strain mice with hepatoma 22a].

The antitumor and immunoadjuvant action of water-soluble N-vinylpyrrolidone co(ter)polymers of different chemical structure is studied. It is established that terpolymer N-vinyl-pyrrolidone (VP)--crotonic acid (CA)--n-crotonoylaminophenol inhibiting the growth of hepatoma 22a by 50-60% possesses an antitumoral action, while copolymer VP-CA has an immunoadjuvant action. These properties of co(ter)polymers are due to their chemical structure and molecular weight, but they do not always correlate between themselves.

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Eksperimental'naia onkologiia

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