Yuanyuan Wang , Lirong Dong , Meng Zhao , Shiyu Yin , Pan Da , Dengfeng Xu , Yifei Lu , Jiayue Xia , Niannian Wang , Shaokang Wang , Guiju Sun
{"title":"循环维生素 C 和 25- 羟维生素 D 浓度与常见精神障碍之间的因果关系--孟德尔随机研究","authors":"Yuanyuan Wang , Lirong Dong , Meng Zhao , Shiyu Yin , Pan Da , Dengfeng Xu , Yifei Lu , Jiayue Xia , Niannian Wang , Shaokang Wang , Guiju Sun","doi":"10.26599/FSHW.2022.9250156","DOIUrl":null,"url":null,"abstract":"<div><p>Mental disorders seriously affect people's health and social stability. This Mendelian randomization (MR) study was designed to investigate the causal relationship between circulating vitamin C (VC) or 25-hydroxyvitamin D (25(OH)D) levels and mental disorders. The data used for the MR analysis were derived from the summary genome-wide association studies (GWAS) database for VC and 25(OH)D and from the FinnGen consortium for fourteen mental disorders. Based on the inverse variance weighted (IVW) method, we found a potential causal association between circulating VC and anxiety disorders (IVW: OR=1.139, 95 %CI: 1.023<img>1.269, <em>P</em> = 0.018). However, no causal association was found between VC or 25(OH)D and other mental disorders (<em>P</em> > 0.05). In the reverse MR analysis, individuals with Alzheimer's disease was causally associated with higher concentrations of circulating VC(<em>P</em> = 0.012), while individuals with anxiety disorders had a negative association between the concentrations of 25(OH)D (<em>P</em> = 0.012). However, the current evidence does not support a causal relationship between VC or 25(OH)D and other mental disorders. In addition, there was no causal association between circulating VC and 25(OH)D (<em>P</em> > 0.05). Future studies are needed to confirm these findings and to elucidate the mechanisms of potential causality.</p></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 4","pages":"Pages 1877-1885"},"PeriodicalIF":5.6000,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213453024000788/pdfft?md5=a68d137e1136f7cfef91205c2d57d51e&pid=1-s2.0-S2213453024000788-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Causal relationship between circulating vitamin C and 25-hydroxyvitamin D concentrations and common mental disorders - a Mendelian randomization study\",\"authors\":\"Yuanyuan Wang , Lirong Dong , Meng Zhao , Shiyu Yin , Pan Da , Dengfeng Xu , Yifei Lu , Jiayue Xia , Niannian Wang , Shaokang Wang , Guiju Sun\",\"doi\":\"10.26599/FSHW.2022.9250156\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Mental disorders seriously affect people's health and social stability. This Mendelian randomization (MR) study was designed to investigate the causal relationship between circulating vitamin C (VC) or 25-hydroxyvitamin D (25(OH)D) levels and mental disorders. The data used for the MR analysis were derived from the summary genome-wide association studies (GWAS) database for VC and 25(OH)D and from the FinnGen consortium for fourteen mental disorders. Based on the inverse variance weighted (IVW) method, we found a potential causal association between circulating VC and anxiety disorders (IVW: OR=1.139, 95 %CI: 1.023<img>1.269, <em>P</em> = 0.018). However, no causal association was found between VC or 25(OH)D and other mental disorders (<em>P</em> > 0.05). In the reverse MR analysis, individuals with Alzheimer's disease was causally associated with higher concentrations of circulating VC(<em>P</em> = 0.012), while individuals with anxiety disorders had a negative association between the concentrations of 25(OH)D (<em>P</em> = 0.012). However, the current evidence does not support a causal relationship between VC or 25(OH)D and other mental disorders. In addition, there was no causal association between circulating VC and 25(OH)D (<em>P</em> > 0.05). Future studies are needed to confirm these findings and to elucidate the mechanisms of potential causality.</p></div>\",\"PeriodicalId\":12406,\"journal\":{\"name\":\"Food Science and Human Wellness\",\"volume\":\"13 4\",\"pages\":\"Pages 1877-1885\"},\"PeriodicalIF\":5.6000,\"publicationDate\":\"2024-05-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2213453024000788/pdfft?md5=a68d137e1136f7cfef91205c2d57d51e&pid=1-s2.0-S2213453024000788-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Food Science and Human Wellness\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2213453024000788\",\"RegionNum\":1,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food Science and Human Wellness","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2213453024000788","RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
Causal relationship between circulating vitamin C and 25-hydroxyvitamin D concentrations and common mental disorders - a Mendelian randomization study
Mental disorders seriously affect people's health and social stability. This Mendelian randomization (MR) study was designed to investigate the causal relationship between circulating vitamin C (VC) or 25-hydroxyvitamin D (25(OH)D) levels and mental disorders. The data used for the MR analysis were derived from the summary genome-wide association studies (GWAS) database for VC and 25(OH)D and from the FinnGen consortium for fourteen mental disorders. Based on the inverse variance weighted (IVW) method, we found a potential causal association between circulating VC and anxiety disorders (IVW: OR=1.139, 95 %CI: 1.0231.269, P = 0.018). However, no causal association was found between VC or 25(OH)D and other mental disorders (P > 0.05). In the reverse MR analysis, individuals with Alzheimer's disease was causally associated with higher concentrations of circulating VC(P = 0.012), while individuals with anxiety disorders had a negative association between the concentrations of 25(OH)D (P = 0.012). However, the current evidence does not support a causal relationship between VC or 25(OH)D and other mental disorders. In addition, there was no causal association between circulating VC and 25(OH)D (P > 0.05). Future studies are needed to confirm these findings and to elucidate the mechanisms of potential causality.
期刊介绍：
Food Science and Human Wellness is an international peer-reviewed journal that provides a forum for the dissemination of the latest scientific results in food science, nutriology, immunology and cross-field research. Articles must present information that is novel, has high impact and interest, and is of high scientific quality. By their effort, it has been developed to promote the public awareness on diet, advocate healthy diet, reduce the harm caused by unreasonable dietary habit, and directs healthy food development for food industrial producers.
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