小茴香种子提取物的植物化学筛选及生物活性研究

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-09-14 DOI:10.1080/11263504.2023.2259375

Apsara Kavital, M. B. Hiremath

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引用次数: 1

摘要

摘要本研究采用气相色谱-质谱联用技术对小茴香种子中的活性成分进行鉴定，并测定其提取物的抗氧化、抗炎和抗菌活性。植物化学分析表明，与其他化合物相比，酚类和类黄酮含量更丰富。DPPH法测定抗氧化活性和白蛋白变性法测定抗炎活性结果表明，丙酮提取物具有显著的抗氧化活性(抑制% - 93.08±0.43%，IC50 - 22.10µg/mL)和抗炎活性(抑制% 80.04±0.52%，IC50 - 43.67µg/mL)。其抑菌活性在10.67±0.75 ~ 16.67±1.07 mm范围内，其中对金黄色葡萄球菌最敏感，其次为枯草芽孢杆菌、蜡样芽孢杆菌、粪肠球菌、铜绿假单胞菌、普通变形杆菌、大肠杆菌和肺炎克雷伯菌。GS-MS分析发现了14种主要的生物活性化合物。茴香籽作为一种有效的抗氧化剂、抗炎剂和抗菌剂，在医药和食品工业中具有广阔的应用前景。关键词:抗炎，抗菌，抗氧化，gc - m植物化学，小茴香，声明，作为对作者和研究人员的服务，我们提供了这个版本的接受稿件(AM)。在最终出版版本记录(VoR)之前，将对该手稿进行编辑、排版和审查。在制作和印前，可能会发现可能影响内容的错误，所有适用于期刊的法律免责声明也与这些版本有关。

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Phytochemical screening and biological activities of Syzygium cumini seed extracts

AbstractThe research aimed to identify the bioactive compounds present in Syzygium cumini seeds by GC-MS and to determine the antioxidant, anti-inflammatory and antibacterial activities of seed extract. Phytochemical analysis revealed that phenols and flavonoids were more abundant in comparison to other compounds. The results of antioxidant activity as measured by DPPH assay and anti-inflammatory activity as measured by albumin denaturation assay revealed that the acetone extract exhibited significant antioxidant (inhibition % - 93.08 ± 0.43% and IC50 - 22.10 µg/mL) and anti-inflammatory activity (inhibition % 80.04 ± 0.52% and IC50 - 43.67 µg/mL). The extracts exhibited remarkable antibacterial activity with the zone of inhibition varying from 10.67 ± 0.75 to 16.67 ± 1.07 mm among which Staphylococcus aureus was more susceptible followed by Bacillus subtilis, Bacillus cereus, Enterococcus faecalis, Pseudomonas aeruginosa, Proteus vulgaris, Escherichia coli and Klebsiella pneumoniae. GS-MS profiling revealed about 14 major bioactive compounds. S. cumini seed could be further utilized in pharmaceutical and food industries as a potent antioxidant, anti-inflammatory and antibacterial agent.Keywords: Anti-inflammatoryAntibacterialAntioxidantGC-MSPhytochemicalsSyzygium cuminiDisclaimerAs a service to authors and researchers we are providing this version of an accepted manuscript (AM). Copyediting, typesetting, and review of the resulting proofs will be undertaken on this manuscript before final publication of the Version of Record (VoR). During production and pre-press, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal relate to these versions also.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.