枸杞和枸杞的甲醇提取物Druce无性系种群。短萼对链脲佐菌素/烟酰胺诱导的2型糖尿病雌性大鼠糖尿病的改善作用

Q2 Medicine

Obesity Medicine Pub Date : 2023-10-30 DOI:10.1016/j.obmed.2023.100517

Sinan Sermet , Muhammet Emin Cam , Ayse Nur Hazar-Yavuz , Turgut Taskin , Gul Sinemcan Kabatas , Yusufhan Yazir , Levent Kabasakal , Hatice Kubra Elcioglu

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引用次数: 0

摘要

背景已知在传统医学中用于治疗糖尿病的有贫铀和果小锥虫亚种。目的探讨枸杞提取物(teucium polium L.甲醇提取物，TP)和小檗(Micromeria fruticosa, L.)的潜在降糖作用及其机制。Druce无性系种群。短萼梅醇提取物(MF)对2型糖尿病大鼠的影响。方法腹腔注射链脲佐菌素(STZ)和烟酰胺(NA)诱导大鼠2型糖尿病(T2DM)。通过生化分析和组织病理学分析，探讨了植物提取物的抗糖尿病作用机制。结果与未治疗的糖尿病大鼠相比，stp和MF治疗可降低血糖水平。TP降低血清TNF-α水平，升高血清和胰腺胰岛素水平，降低肾脏SGLT-2水平，降低回肠GLUT-2水平;MF降低血清和胰腺中TNF-α水平，升高胰岛素水平，升高回肠中GLP-1水平，降低GLUT-2水平，降低肾脏中SGLT-2水平。治疗改善了胰腺、肾脏和肝脏的组织病理学结果。结论TP和MF均具有潜在的降糖作用，可能对2型糖尿病有一定的治疗作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The methanolic extracts of Teucrium polium L. and Micromeria fruticosa (L.) Druce subsp. brachycalyx P. H. Davis improve diabetes in streptozotocin/nicotinamide-induced type 2 diabetic female Sprague Dawley rats

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Background

Teucrium polium and Micromeria fruticosa subspecies are known to be used in traditional medicine for diabetes treatment.

Objective

The present study aimed to examine the potential antidiabetic effects and the mechanisms of antidiabetic actions of Teucrium polium L. methanolic extract (TP) and Micromeria fruticosa (L.) Druce subsp. brachycalyx P. H. Davis methanolic extract (MF) on rats with type 2 diabetes mellitus (DM).

Methods

Streptozotocin (STZ) and nicotinamide (NA) were injected intraperitoneally to induce type 2 diabetes mellitus (T2DM) in rats. Plant extracts’ antidiabetic mechanisms of action were investigated with biochemical analyses and histopathological analyses performed.

Results

TP and MF treatments reduced the blood glucose levels compared to the untreated diabetic rats. TP reduced TNF-α levels in serum, increased insulin levels in serum and pancreas, reduced SGLT-2 levels in kidneys, reduced GLUT-2 levels in the ileum; and MF reduced TNF-α levels, and increased insulin levels in serum and pancreas, increased GLP-1 levels, and reduced GLUT-2 levels in the ileum, and reduced SGLT-2 levels in kidneys. Treatments improved the histopathological results in the pancreas, kidney, and liver.

Conclusions

The results presented in this study demonstrated that TP and MF both have potential antidiabetic effects and may be effective in T2DM treatment.

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来源期刊

Obesity Medicine Medicine-Public Health, Environmental and Occupational Health

CiteScore

5.50

自引率

0.00%

发文量

审稿时长

40 days

期刊介绍： The official journal of the Shanghai Diabetes Institute Obesity is a disease of increasing global prevalence with serious effects on both the individual and society. Obesity Medicine focusses on health and disease, relating to the very broad spectrum of research in and impacting on humans. It is an interdisciplinary journal that addresses mechanisms of disease, epidemiology and co-morbidities. Obesity Medicine encompasses medical, societal, socioeconomic as well as preventive aspects of obesity and is aimed at researchers, practitioners and educators alike.