经皮给药用热敏微凝胶的研制

2ND INTERNATIONAL CONFERENCE ON FRONTIERS OF BIOLOGICAL SCIENCES AND ENGINEERING (FSBE 2019) Pub Date : 2020-02-19 DOI:10.1063/5.0000058

Xiaozhu Sun, Na Wan

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引用次数: 0

摘要

以CaCO3为模板制备热敏微凝胶，其体积随温度变化。将姜黄素包埋在羟丙基-β-环糊精(HP-β-CD)中，通过捏合法制备包合物，并将包合物装入微凝胶中。获得的药物释放谱被发现在LCST以上的样品中有增强的释放，并且受扩散控制机制的控制。负载络合物的微凝胶的渗透效率与温度有关。

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Development of thermosensitive microgel for transdermal drug delivery

Thermosensitive microgels were prepared by CaCO3 template, which exhibited volume change with temperature. Curcumin were encapsulated into hydroxypropyl-β-cyclodextrin (HP-β-CD) to fabricate inclusion complexes through the kneading way, which were then loaded into these microgels. Drug release profiles obtained were found to have enhanced release for the samples above LCST and governed by a diffusion-controlled mechanism. Complex-loaded microgel presented permeation efficiency in respect to temperature.

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2ND INTERNATIONAL CONFERENCE ON FRONTIERS OF BIOLOGICAL SCIENCES AND ENGINEERING (FSBE 2019)

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