超声造影剂微泡的理论与实验分析:Sonovue

2015 8th International Conference on Biomedical Engineering and Informatics (BMEI) Pub Date : 2015-10-01 DOI:10.1109/BMEI.2015.7401521

Shuying Li, Yurong Huang, Yi Cheng, Jinhua Yu, Yuanyuan Wang

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引用次数: 0

摘要

Sonovue是一种超声造影剂(UCA)，由脂质制成稳定的外壳，里面是SF6。由于其独特的声学特性，在超声诊断和治疗中得到了广泛的应用。在某些情况下，散射信号的二次谐波应该足够强，以帮助形成高质量的图像。为了更好地利用气泡获得散射信号中足够强度的二次谐波，本文基于之前提出的几种模型，对气泡的行为进行了数值模拟和相应的实验分析。本文用二次谐波与基波的比值来评价气泡的振荡。并对不同的仿真模型进行了比较，设计了相应的仿真平台。最后，我们发现当仿真中驱动压力在150KPa以下或实验中驱动压力在200KPa以下时，二次谐波会有显著的增长。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The theoretical and experimental analysis of ultrasound contrast agent micro bubbles: The Sonovue

Sonovue is a kind of ultrasound contrast agent (UCA) with a stable shell made by lipid, within which is SF6. Due to the specific acoustic characteristics, UCA has been widely used in ultrasound diagnosis and therapy. In some cases, the 2nd harmonic wave of the scattered signal should be strong enough to help form a high quality image. To better utilize the bubbles to get enough intensity of the 2nd harmonic wave of the scattered signal, numerical simulation and corresponding experiments based on the several models proposed before have been analyzed to study the behavior of the bubbles. In this paper, we use the ratio of the second harmonic wave and fundamental wave to evaluate the oscillation of the bubbles. Besides, we have compared different simulation models and designed corresponding platform of phantom study. Finally, we find that the second harmonic wave will get a remarkable growth when the driving pressure is under 150KPa in the simulation or under 200KPa in the experiment.

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2015 8th International Conference on Biomedical Engineering and Informatics (BMEI)

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