人重组干扰素- α 2在大鼠血浆、肝脏和实验性肝转移中的分布。

Molecular biotherapy Pub Date : 1990-12-01

V Bocci, F Carraro, A Naldini, P P Cagol, E M Pasqual, C Prevaldi, D Casara

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引用次数: 0

摘要

已经确定，在实体肿瘤中，即在门内注射Walker癌256细胞后引起的大鼠肝转移中，干扰素活性可以忽略的几个可能原因之一是，与正常肝脏和血浆相比，转移灶间质液中的干扰素水平明显较低。

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Distribution of human recombinant interferon-alpha 2 in rat plasma, liver, and experimental liver metastases.

It has been ascertained that one of several possible reasons for negligible interferon activity in solid tumors, namely, hepatic metastases induced in rats after intraportal injection of Walker carcinoma 256 cells, is the significantly lower levels of interferon in the interstitial fluid of metastases in comparison to normal liver and plasma.

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Molecular biotherapy

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