The evolution of skin tissue engineering: A review on recent trends and advances

Skin plays an indispensable role in protection, sensation, temperature regulation and so on. Autologous skin grafting is the main method to treat skin wounds. However, patients with large-scale skin defects often face the problem of insufficient autologous skin, and the emergence of tissue engineering effectively compensates for the lack of skin sources. In recent years, with the efforts of scientists, skin tissue engineering technology has made some progress. In this paper, the development of skin tissue engineering in scaffold materials, seed cells and growth factors are reviewed, hoping to provide reference for the progress of skin tissue engineering.