特发性帕金森病和疲劳

Erdoğan Hacı Ali, Yayla Vildan, Sözer Nejla, Aydın Filiz Yıldız, Acır Ibrahim, Vural Meltem
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摘要

疲劳是特发性帕金森病(IPD)常见的非运动性症状。目的是研究IPD患者疲劳与情绪障碍临床表现之间的关系。材料与方法:共纳入39例IPD患者。在IPD中评估疲劳严重程度和人口学特征与治疗之间的关系。采用疲劳严重程度量表(FSS)评价疲劳程度。采用改进的Hoehn和Yahr量表对运动障碍进行评分。采用医院焦虑抑郁量表(HADS)评估患者是否存在抑郁和焦虑。结果:患者平均年龄70.62±8.35岁。其中男性23人,女性16人。平均病程为6.18±3.35年。根据FSS测量疲劳程度分为两组,第一组小于5分,第二组大于等于5分。两组患者的平均年龄、平均发病年龄、平均病程比较,差异均无统计学意义(p > 0.05)。两组患者在抑郁、焦虑值和抗帕金森治疗方面无显著差异(p > 0.05)。疲劳程度与HADS焦虑水平相关(p < 0.05)。讨论:疲劳是临床随访中被低估的一种重要的非运动性症状。我们没有发现疲劳与年龄、疾病发作时间或药物使用之间的任何相关性。疲劳评分与抑郁、疼痛无显著相关性。然而,焦虑得分高的患者和女性的疲劳得分更高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Idiopathic parkinson’s disease and fatigue
Introduction: Fatigue is a common non-motor symptom of Idiopathic Parkinson’s Disease (IPD). The aim is to research the relationship between fatigue of IPD patients and the clinical findings, of mood disorders. Material and methods: A total of 39 patients with IPD were included in the study. The relationship between fatigue severity and demographic characteristics and the treatment was evaluated in IPD. The severity of fatigue was evaluated by Fatigue Severity Scale (FSS). Motor impairment was scored by the modified Hoehn and Yahr scale. The patients were assessed for the presence of depression and anxiety with the Hospital Anxiety and Depression Scale (HADS). Results: The mean age of the patients was 70.62 ± 8.35 years. 23 were men and 16 were women. The mean disease duration was 6.18 ± 3.35 years. The patients were assigned into two groups according to the presence of fatigue measured by FSS with less than 5 (Group I) and 5 or more (Group II). There were no statistically significant differences between the two groups with respect to mean age, mean age of onset, and mean disease duration of the patients (p > 0.05). There were no significant differences between the two groups for HADS depression, anxiety values, and terms of antiparkinsonian therapies (p > 0.05). The severity of fatigue was correlated with the HADS anxiety levels (p < 0.05). Discussion: Fatigue is an important non-motor symptom that is underestimated in clinical follow-up. We didn’t find any correlation between fatigue and age, duration of disease onset, or drug use. There was no significant correlation between the fatigue score and depression, and pain. However, the fatigue scores were higher in patients with high anxiety scores and females.
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