The Effect of Bariatric Surgery on Migraine Headache in Morbid Obese Patients

Background: Migraine is a common and chronic neuro-inflammatory disease with progressive and episodic headache manifesta-tion that leads to considerable disability. Many studies recognized that obesity is a risk factor for progression of migraine. Further-more,bothmigraineandobesityishighlyprevalentandimportantriskfactorsof chroniccardiovasculardisease,stroke,andother inflammatory disease. Thus, it is very important if weight loss could alleviate the migraine headache and its related comorbidities. Aim: The present review article was conducted to assess the potential effect of Bariatric surgery on improvement of migraine headaches in morbid obese patients. surgery”,“gastricBypass”;“MorbidObesity”and“Migraineheadache”forinterventionalstudiesinvestigatedtheimpactof Bariatric surgery on migraine headache. Results: The findings suggest significant improvement in headache frequency, duration, migraine-induced discomfort and migraine derived symptoms (nausea, phono and photophobia and) occurs as early as 3 months after bariatric surgery. Moreover, patients who had higher weight loss were more likely to experience a 50% or higher reduction in headache frequency, duration and severity. Conclusions: Theentireevidencessuggestpatientswithindicationsof bariatricsurgerywillbenefitfromtheimprovementsinthe Migraine headache after surgery. However, it remains unclear whether Bariatric-induced endocrine, gut-brain axis alterations, or reduction in adipokine contribute to migraine improvement, so further studies are needed to confirm and clarify these findings.