Impact of Depth of Invasion on Number of Cervical Lymph Nodes Infiltration in Cancer Lip

Background: Lip cancer is a malignancy that results from the autonomous and uncontrolled cell growth in the lips. Lip cancer is a part of head and neck cancers and may occur together with oral cancer or may be one symptom of oral cancer. Lip cancers come in the form of squamous cell carcinoma with abnormal growth of the flat cells on the lips. Aim of the Work: To evaluate the relation and impact of the depth of invasion in mm of tumor to number of lymph nodes infiltrated. Material and Methods: 42 patients had lip cancer proved by biopsy or clinically to be malignant, undergone wide excision with safety margin with reconstruction either by primary repair or by loco regional flap with cervical nodes block dissection to evaluate the positive nodes number in relation to the depth of tumor. Results: Patients under went excision of lesion with lymph nodes with the increase in number of nodes infiltrated in proportion to the depth of invasion with increase recurrence rate irrespective to age of patients. Conclusion: Depth of tumor and number of lymph nodes infiltrated are important prognostic factors in lip cancer. be used as a predictor of neck metastasis in squamous cell carcinoma of the lower lip. This study was a retrospective analysis of the clinic pathologic factors related to Late Lymph Node Metastasis (LLNM) occurrence and to identify patients at risk, to improve neck management and prognostic outcomes in stage I and II SCC of the lip. cervical lymph node metastasis of oral squamous cell carcinoma of cN0; and further analysis found that the growth pattern, degree of differentiation, depth of invasion were all independent risk factors for cervical lymph node metastasis.