{"title":"MicroRNA let-7e和miR-140作为变形性关节疾病的生物标志物","authors":"P. T. Zhurko, I. Koktysh, R. Smolyakova","doi":"10.46646/sakh-2021-2-55-58","DOIUrl":null,"url":null,"abstract":"The circulating microRNAs (let-7e and miR-140) expression levels were studied in the plasma of peripheral blood and synovial fluid of patients with gonarthrosis and coxarthrosis. There was a statistically significant decrease in the expression of miR-140 in synovial fluid and let-7e in the peripheral blood of patients with osteoarthritis (p <0.05). MicroRNA let-7e characterizes comorbidity and indicates the development of metabolic syndrome. It was established a correlation between the microRNAs expression levels and the disease severity.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":"77 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"MicroRNA let-7e AND miR-140 AS BIOMARKERS OF DEFORMING JOINT DISEASES\",\"authors\":\"P. T. Zhurko, I. Koktysh, R. Smolyakova\",\"doi\":\"10.46646/sakh-2021-2-55-58\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The circulating microRNAs (let-7e and miR-140) expression levels were studied in the plasma of peripheral blood and synovial fluid of patients with gonarthrosis and coxarthrosis. There was a statistically significant decrease in the expression of miR-140 in synovial fluid and let-7e in the peripheral blood of patients with osteoarthritis (p <0.05). MicroRNA let-7e characterizes comorbidity and indicates the development of metabolic syndrome. It was established a correlation between the microRNAs expression levels and the disease severity.\",\"PeriodicalId\":385455,\"journal\":{\"name\":\"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2\",\"volume\":\"77 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-05-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.46646/sakh-2021-2-55-58\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.46646/sakh-2021-2-55-58","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
MicroRNA let-7e AND miR-140 AS BIOMARKERS OF DEFORMING JOINT DISEASES
The circulating microRNAs (let-7e and miR-140) expression levels were studied in the plasma of peripheral blood and synovial fluid of patients with gonarthrosis and coxarthrosis. There was a statistically significant decrease in the expression of miR-140 in synovial fluid and let-7e in the peripheral blood of patients with osteoarthritis (p <0.05). MicroRNA let-7e characterizes comorbidity and indicates the development of metabolic syndrome. It was established a correlation between the microRNAs expression levels and the disease severity.
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