2022年1月23日:100年前,胰岛素治疗的奇迹今天还在继续

Il Diabete Pub Date : 2022-05-12 DOI:10.30682/ildia2201a
Geremia B. Bolli, Francesca Porcellati, P. Lucidi, Carmine G. Fanelli
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引用次数: 0

摘要

1922年1月23日,在多伦多总医院,第一次成功地皮下注射了一种胰腺提取物,由班廷制备,由科利普纯化,用于伦纳德·汤普森,一个患有糖尿病酮症酸中毒的小男孩。这一天是胰岛素疗法的诞生,多年来挽救了数千万人的生命。动物提取的胰岛素经过不断的纯化,直到用rDNA技术获得人胰岛素和胰岛素类似物,根据生理原理替代胰岛素。今天,1型糖尿病的基础胰岛素治疗和2型糖尿病的基础胰岛素治疗(可能与GLP-1 RA联合)仍然是糖尿病胰岛素治疗的巩固金标准。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
23 gennaio 2022: 100 anni fa il miracolo della terapia insulinica che continua oggi
It was January 23, 1922, when the first successful subcutaneous injection of a pancreatic extract, prepared by Banting and purified by Collip, was administered to Leonard Thompson, a young boy in diabetic ketoacidosis, at the Toronto General Hospital. That day is the birth of insulin therapy which over the years has saved tens of millions of lives of people. Animal extracted insulin has been continuously purified until human insulin and the insulin analogs have been obtained with the rDNA technique to substitute insulin according to physiology. Today basal-bolus insulin therapy in type 1 diabetes, and basal insulin in type 2 (possibly in combination with GLP-1 RA) remain the consolidated gold standards of insulin therapy in diabetes.
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