{"title":"结肠癌miRNA靶基因的全局分析","authors":"M. Pradhan, L. Ledford, Yogesh Pandit, M. Palakal","doi":"10.1109/BIBM.2010.5706588","DOIUrl":null,"url":null,"abstract":"In this paper we present a global analysis of colon rectal cancer genes and their associated miRNAs. Significant genes in colon cancer were obtained by mining the literature and cancer related miRNAs were obtained from miRbase. Five different features were used to analyze to obtain a global gene-miRNA profile. By combining the topological features along with miRNA-gene associations and gene propensity measures, we identified a set of genes and modules that are significant in CRC. The proposed methodology identified 123 significant modules of miRNA-genes that can be further studied for understanding the disease and marker discovery.","PeriodicalId":275098,"journal":{"name":"2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","volume":"12 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Global analysis of miRNA target genes in colon rectal cancer\",\"authors\":\"M. Pradhan, L. Ledford, Yogesh Pandit, M. Palakal\",\"doi\":\"10.1109/BIBM.2010.5706588\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In this paper we present a global analysis of colon rectal cancer genes and their associated miRNAs. Significant genes in colon cancer were obtained by mining the literature and cancer related miRNAs were obtained from miRbase. Five different features were used to analyze to obtain a global gene-miRNA profile. By combining the topological features along with miRNA-gene associations and gene propensity measures, we identified a set of genes and modules that are significant in CRC. The proposed methodology identified 123 significant modules of miRNA-genes that can be further studied for understanding the disease and marker discovery.\",\"PeriodicalId\":275098,\"journal\":{\"name\":\"2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)\",\"volume\":\"12 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/BIBM.2010.5706588\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/BIBM.2010.5706588","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Global analysis of miRNA target genes in colon rectal cancer
In this paper we present a global analysis of colon rectal cancer genes and their associated miRNAs. Significant genes in colon cancer were obtained by mining the literature and cancer related miRNAs were obtained from miRbase. Five different features were used to analyze to obtain a global gene-miRNA profile. By combining the topological features along with miRNA-gene associations and gene propensity measures, we identified a set of genes and modules that are significant in CRC. The proposed methodology identified 123 significant modules of miRNA-genes that can be further studied for understanding the disease and marker discovery.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
