实验性全身性炎症和创伤性脑损伤左肺根的形态功能特征

Zinoviev S.V., Plekhova N.G., Shumatov V.B.
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引用次数: 0

摘要

全身性炎症是一种复杂的综合征,就其对身体的意义而言。全身性炎症可能是外伤性脑损伤发病机制的一部分。研究目的:研究目的:全身性炎症和创伤性脑损伤左肺实验根的结构和功能特征。材料和方法。为了再现外伤性脑损伤,采用了改良的减重模型。以白化大鼠为实验动物。为了造成伤害,使用了一个负载(重量为200 g)的装置,该装置从1米的高度落在动物头部的顶骨区域。为了研究实验性发热,给动物肌肉注射药典形式的LPS热原溶液。结果。对大鼠左肺尾叶支气管进行了形态学和组织化学研究。左肺尾叶支气管的平均支气管上皮高度在创伤性脑损伤和全身性炎症合并时下降最为显著。支气管上皮保留其纤毛。创伤性脑损伤后第6天,大鼠支气管上皮嗜银性和核仁大小明显增加。结缔组织纤维呈嗜银性。结论。在外伤性脑损伤和全身性炎症相结合的情况下,大鼠左肺尾叶支气管外膜与左肺尾叶静脉外膜接触处的肥大细胞含量变化最具信息性。位于肺叶支气管和肺叶肺外膜接触部位的乳腺细胞,在人和大鼠中仍然是一个研究不足的细胞群。提示全身性炎症合并颅脑损伤的发病机制可能与大叶支气管支气管上皮和大叶肺静脉外膜肥大细胞的营养不良改变有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
MORPHOFUNCTIONAL CHARACTERISTICS OF THE ROOT OF THE LEFT LUNG IN EXPERIMENTAL SYSTEMIC INFLAMMATION AND TRAUMATIC BRAIN INJURY
Systemic inflammation is a complex syndrome in terms of its significance for the body. Systemic inflammation may be part of the pathogenesis of traumatic brain injury. Purpose of the study: Purpose of the study: Structural and functional characteristics of the experimental root of the left lung in systemic inflammation and traumatic brain injury. Materials and methods. To reproduce traumatic brain injury, a modified weight-drop model was used. Albino rats were studied experimental animals. To inflict injury, a device with a load (weight 200 g) was used, which falls from a height of 1 m onto the parietal region of the animal's head. For the study of experimental fever, the animals were injected intramuscularly with the pharmacopoeial form of LPS pyrogenal solution. Results. A morphological and histochemical study of the caudal lobar bronchus of the left lung of rats was carried out. The average height of the bronchial epithelium of the caudal lobar bronchus of the left lung most significantly and significantly decreases with a combination of traumatic brain injury and systemic inflammation. The bronchial epithelium retains its cilia. With the combination of SI and traumatic brain injury on the 6th day, argentophilia and an increase in the size of the nucleoli of the bronchial epithelium significantly increase. Argyrophilia of connective tissue fibers is revealed. Conclusion. With a combination of traumatic brain injury and systemic inflammation, the most informative changes in the content of mast cells are at the point of contact of the adventitial membrane of the caudal lobar bronchus of the left lung of the rat with the adventitial membrane of the caudal lobar vein of the left lung. Mastocytes localized at the site of contact between the adventitial membranes of lobe bronchus and lobe vien remain an insufficiently studied cell population of this differ on in both humans an rat. Thus, it is revealed that the pathogenesis of systemic inflammation combined with craniocerebral injury may involve dystrophically altered bronchial epithelium of the lobar bronchi, and mast cells of the adventitia of the lobar pulmonary veins.
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