特定饮食环境下microrna调节活动的条件模型

2010 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS) Pub Date : 2010-11-01 DOI:10.1109/GENSIPS.2010.5719690

Chen Zhao, I. Ivanov, Manasvi Shah, L. Davidson, R. Chapkin, E. Dougherty

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引用次数: 1

摘要

我们首次研究了一种基于条件的模型的适用性，该模型由microRNA、总mRNA和多体mRNA的表达值组成，这些数据来自两种饮食环境的实验。结果表明，一些microrna可能参与了大量基因的调控，而不仅仅是它们假定的靶标。此外，肠道microRNA的调控活性似乎依赖于mRNA在细胞内的亚细胞位置。

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Conditioning-based model for the regulatory activities of microRNAs in specific dietary contexts

For the first time, we studied the applicability of a conditioning-based model to a heterogeneous data set composed of expression values for microRNA, total mRNA and polysomal mRNA resulting from experiments about two dietary contexts. The results suggest that some of the microRNAs are likely to be involved in the regulation of a large set of genes and not just their putative targets. Furthermore, the regulatory activities of intestinal microRNA appear to be dependent on the sub-cellular location of mRNA within the cell.

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2010 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)

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