地塞米松对实验小鼠肝肾功能的生化变化。

Sumer 1 Pub Date : 2023-08-15 DOI:10.21931/rb/css/s2023.08.01.3

Alaa S. Kathim, Murtadha F. AL-Hillo

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引用次数: 0

摘要

背景:本研究旨在验证地塞米松对雌雄小鼠肝、肾等不同器官生化变化的影响。材料与方法:选用肌肉发达的雄性和雌性小鼠48只。为了研究地塞米松对肝脏和肾脏器官生化变化的影响，小鼠连续给予低剂量(2mg/kg)和高剂量(4mg /kg)地塞米松1个月。结果:肝酶(ALP、AST、ALT)显著升高(P<0.05)。与对照组相比，注射了农药的实验组和雌雄小鼠的尿素和肌酐水平也有所上升。关键词:小鼠，组织学，肝，肾，地塞米松，毒性

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Biochemical Changes of Dexamethasone on Liver and Kidney Functions in Laboratory Mice Mus musculus L.

Background: The present study sought to verify the effect of dexamethasone on the biochemical changes in different organs, such as liver and kidney organs of both sexes, male and female mice. Materials & Method: Muc muscular males and female mice (n=48) were used. To determine the effects of dexamethasone on the biochemical changes of liver and kidney organs, mice received a low dose (2mg/kg) and a high dose (4 mg/kg) of dexamethasone continuously for one month. Result: The results showed a significant increase (P<0.05) in Liver enzymes (ALP, AST, ALT). The urea and creatinine levels also increased in the treated mice and both sexes with the pesticide compared with the control group. Keywords: mice, histological, liver, kidney, dexamethasone, toxicity

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Sumer 1

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