壳聚糖衍生的合成离子交换剂:特性与应用

R. Dongre
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引用次数: 6

摘要

今天,日益增长的科学技术需求探索了各种生物聚合物,以在其现代发展中获得新的用途。因此,多糖具有巨大的前景,并极大地满足了这种日益增长的需求。其中,几丁质是仅次于纤维素的第二普遍存在的物质,由β-[1,4]-2-乙酰氨基-2-脱氧-d-葡萄糖柔性骨架组成,经过必要的物理化学特征的改变,其高度复杂的用途取代了纤维素。壳聚糖具有独特的生物相容性、无毒性、抗凝血性和抗微生物性,为解决许多具有挑战性的问题提供了强有力的解决方案。因此,许多产品,如生物标记物,生物传感器,量子点是通过采用高产壳聚糖基质制备的。壳聚糖化学的进步在化妆品、制药、纳米生物技术、水净化等方面提供了明确的工业用途。壳聚糖复合材料具有增强的黏附性,有助于在靶向特定载体上安全成功地释放DNA/SiRNA/组织,并具有生物利用度。ZnO, ZnS, TiO2填充/施加于壳聚糖和由此产生的杂化物,量子点,表面活性微胶囊和纳米颗粒被用作生物传感器,生物标志物,吸附剂,提供革命性的医疗用途。纳米集成壳聚糖具有互补优势和多种用途,即纳米电子高分辨率器件,用于体内成像,疾病诊断,产生新的治疗和智能组织工程支架。本章展示了壳聚糖基质在生物、化学、聚合物和制药等领域的广泛应用。还有药物输送。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chitosan-Derived Synthetic Ion Exchangers: Characteristics and Applications
Today growing science and technological needs explored various biopolymers to procure novel utilities in its modern developments. Consequently, polysaccharides embraced huge prospective and vastly caters such desired growing needs. Amid, chitin the second most ubiquitous after cellulose comprise of β-[1,4]-2-acetamido-2-deoxy-d-glucose flexible skeleton undergo alteration for requisite physico-chemical features and its highly sophisticated utility superseded counterpart cellulose. Chitosan have unique parameters namely bio-compatibility, non-toxicity, hemeostaticity, anti-microbials which offer com- petent solutions of many challenging problems. Thus, many products namely biomark -ers, biosensors, quantum dots are fabricated via adoptable productive chitosan matrixes. Advancement in chitosan chemistry proffers unambiguous industrial utility in cosmetics, pharmaceuticals, nanobiotechnology, water purifications etc. Chitosan composites own enhanced muco-adhesivity that aids pharmacological safe and successful DNA/SiRNA/ tissue releases with bioavailability at target specific carriers. ZnO, ZnS, TiO2 filled/ imposed in chitosan and resultant hybrids, quantum dots, surface active microcapsules and nanoparticles are used as biosensors, bio-markers, adsorbents that proffers revolu- tionary medical usage. Nanointegrated chitosan own complementary strengths and possess assorted utility namely nano-electronic high-resolution devices, for in-vivo imaging, diseases diagnosis, generating new therapeutic and smart tissue engineering scaffolds. Novel modalities with innovative formulations are skillfully designed via chitosan matrix for myriad benefit in biology, chemistry, polymer, and pharmaceutics are displayed in this chapter. and drug delivery.
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