毛细管数对复合微流控过滤芯片上癌细胞捕获效率的影响

2015 28th IEEE International Conference on Micro Electro Mechanical Systems (MEMS) Pub Date : 2015-03-02 DOI:10.1109/MEMSYS.2015.7050989

Cong Zhao, Rui Xu, Kui Song, Dayu Liu, Shuo Ma, Chen Tang, Chun Liang, Y. Zohar, Yi-Kuen Lee

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引用次数: 4

摘要

本文系统研究了毛细管数(Ca)对复合微流控过滤芯片上癌细胞捕获效率的影响。通过改变微芯片实验中的Ca，实验研究了黏性力和细胞皮层张力之间的平衡对捕获效率的影响，并进行了理论分析。首次给出了微滤芯片捕获效率的“相图”，作为归一化细胞直径和Ca的函数。已经确定了Ca的临界值，约为0.03~0.04，可以提高癌细胞的捕获效率。发现相图与先前其他人报道的微滤系统中癌细胞捕获的结果一致。该图可作为设计下一代分离循环肿瘤细胞微滤装置的有用工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Capillary number effect on the capture efficiency of cancer cells on composite microfluidic filtration chips

We present a systematic study of the Capillary number (Ca) effect on the capture efficiency of cancer cells on a composite microfluidic filtration chip. By altering the Ca in microchip experiments, the balance between the viscous force and the cell cortical tension affecting the capture efficiency has been investigated experimentally and analyzed theoretically. A `Phase Diagram' for the capture efficiency of microfiltration chips is presented, for the first time, as a function of the normalized cell diameter and Ca. A critical value of Ca, around 0.03~0.04, has been identified for enhancing the capture efficiency of cancer cells. The phase diagram is found to be consistent with the results of cancer-cell capture in microfiltration systems reported previously by others. The diagram can be a useful tool for designing the next generation microfiltration devices for isolating circulating tumor cells.

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来源期刊

2015 28th IEEE International Conference on Micro Electro Mechanical Systems (MEMS)

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