基因表达的时间调控

M. Morange
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引用次数: 4

摘要

分子生物学对调控基因表达的机制给出了一个静态而非动态的视角。在解释现存现象时,遗传学已经把有限的地位让给了时间。生物学家使用的x射线晶体学等技术支持了这种静态视觉。然而,在细胞对外部信号的反应过程中,在生物体的生命和衰老过程中,甚至在进化过程中发生的生命形式的演代过程中,时间都是控制基因表达的重要参数。由于新技术的爆发使人们能够接触到活细胞内发生的快速事件,模型正在缓慢地移动。一种新的动态视野正在逐步取代旧的视野。这些变化对未来生物形态的影响仍然未知。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Temporal regulation of gene expression
Molecular biology gives a static--not a dynamic--vision of the mechanisms regulating gene expression. Genetics already gave to time a limited place in the explanation of living phenomena. Such a static vision is supported by the techniques--such as X-ray crystallography--used by the biologists. However time is an important parameter in the control of gene expression during the cellular response to external signals, during life and aging of organisms or even in the succession of living forms which takes place in evolution. Models are slowly moving, due to the eruption of new technologies giving access to the fast events which occur inside living cells. A new dynamic vision is progressively replacing the old one. The consequences of these changes on the form of the future biology remain still unknown.
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