Research progress of dual-model contrast based on the magnetic nano particles

The iron oxide nanoparticles used in the combined imaging technology of PET and MRI have excessive iron in the local area of the patient, causing cytotoxicity and other problems. Therefore, in this work, three different coating-coated nano-iron oxide particles (Fe3O4 NPs) are introduced. First, different lengths of heparin oligosaccharide (HO) are coupled to the nanoparticles’ surface, improving the imaging contrast by controlling the length of HO. The second method is to coat the surface of nanoparticles with N, N, N-trimethyl chitosan (TMC) coating to couple breast cancer receptors to TMC, so as to realize targeted detection of breast cancer. The third method aims at improving the stability and biocompatibility of imaging agents in the human body and reduce the cytotoxicity of the imaging agent in the liver, such as coating the surface of nanoparticles with hydroxyapatite coating.