用于增强体外受精的微流体装置

2017 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS) Pub Date : 2017-07-26 DOI:10.1109/TRANSDUCERS.2017.7994360

Yung-Chin Tzeng, Yueh-Jen Chen, Chang Chuan, L. Pan, F. Tseng

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引用次数: 0

摘要

我们建议将高质量精子分选器和卵母细胞带去除器以及孵育器两种设备协同操作，以提高体外受精(IVF)的成功率和效率。高质量的精子分选器可在几分钟内轻轻分选出大量精子，为少精症患者保持较高的存活率。卵母细胞去带孵育装置可在轻轻去除卵母细胞外壳后迅速减少酶收缩。实验结果表明，这两种装置不仅提供了一种更简单、更快速的方法来分选运动精子，更好地保存脱带卵母细胞的活力，而且提高了精子在卵母细胞上的附着率，从而提高了受精效果。

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Microfluidic devices for enhancing in-vitro fertilization

We propose the synergic operation of two devices that consist of a high quality sperm sorter and an oocytes zona-removal as well as incubation device for promoting the successful rate and the efficiency of In-vitro fertilization (IVF). The high quality sperm sorter can gently sort out large number of sperms in few minutes and keep high survival rate for oligospermia patients. The oocytes zona-removal and incubation device can rapidly reduce enzyme contraction after gently removing oocytes shell. Experiment results showed that these two devices not only provide an easier and faster method to sort out motile sperms as well as better preserve the viability of dezona oocytes, but also increase the attachment rate of sperms on oocytes for enhancing fertilization.

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2017 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS)

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