托瑞米芬对绝经后女性雌激素引发阴道粘膜的影响

J. Mäenpää , K.-O. Söderström , M. Grönrnroos , E. Taina , A. Hajba , L. Kangas
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引用次数: 12

摘要

在绝经后妇女志愿者中,每天服用20毫克托瑞米芬,连续7天,每天服用68毫克,连续5天,并在整个研究过程中持续服用戊酸雌二醇(每天口服2毫克)。对照组单独使用雌激素,参照组使用雌激素加他莫昔芬60 mg,疗程5天。没有任何治疗反对雌激素对子宫内膜的作用,但68 mg托瑞米芬和60 mg他莫昔芬均在第13天统计学上显著降低了阴道细胞的成熟度指数。在第18天使用20mg托瑞米芬也明显减少。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of toremifene on estrogen primed vaginal mucosa in postmenopausal women

The antiestrogenic effect of 20 mg toremifene daily for 7 days and 68 mg for 5 days was studied in postmenopausal women volunteers primed for 7 days with estradiol valerate (2 mg daily orally) which was continued throughout the study. A control group received estrogen only and a reference group estrogen with 60 mg tamoxifen for 5 days.

No treatment opposed the action of the estrogen on the endometrium but both 68 mg toremifene and 60 mg tamoxifen statistically significantly decreased the maturity index of vaginal cells on day 13. A decrease was also evident on day 18 with 20 mg toremifene.

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